Evidence map›Paper›PMID 30762195›Full record

ArticleLasers in medical science2019

Theoretical and experimental modeling of interstitial laser hyperthermia with surface cooling device using Nd

D V Pominova, I D Romanishkin, P V Grachev, A V Borodkin, A S Vanetsev, E O Orlovskaya, Yu V Orlovskii, I Sildos, V B Loschenov, A V Ryabova

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Article in Lasers in medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

D V PominovaProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str. 38, Moscow, Russia, 119991. pominovadv@gmail.com.ORCID http://orcid.org/0000-0002-3634-8709
I D RomanishkinProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str. 38, Moscow, Russia, 119991.
P V GrachevProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str. 38, Moscow, Russia, 119991.
A V BorodkinProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str. 38, Moscow, Russia, 119991.
A S VanetsevInstitute of Physics, University of Tartu, W. Ostwaldi st. 1, 50411, Tartu, Estonia.
E O OrlovskayaProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str. 38, Moscow, Russia, 119991.
Yu V OrlovskiiProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str. 38, Moscow, Russia, 119991.
I SildosInstitute of Physics, University of Tartu, W. Ostwaldi st. 1, 50411, Tartu, Estonia.
V B LoschenovProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str. 38, Moscow, Russia, 119991.
A V RyabovaProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilov str. 38, Moscow, Russia, 119991.

Funding

Ministry of Education and Science of the Russian Federation (RU) RFMEFI61615X0064
6 · The paper itself

Abstract

To improve methods of laser hyperthermia for the treatment of bulk malignant neoplasms, an urgent task is the development of techniques and devices that automatically control heating at a given tissue depth and ensure its uniformity. The article proposes the concept of a system for performing hyperthermia with real-time spectroscopic temperature control and surface cooling, which allows to record spectra of diffusely scattered radiation and fluorescent signal from various depths of biological tissues by the means of the variation of the angle and distance between the fiber source of laser radiation and the receiving fiber. Theoretical and experimental modeling of the spatial distribution of diffusely scattered radiation and temperature inside the tissue with a fiber optic device providing surface cooling of the irradiated tissue, and recording spectral information from a given depth in real time, is presented. Simulation of radiation propagation in biological tissues, depending on the distance between the source and the receiver and the angle of their tilt, was carried out using the Monte Carlo method. Modeling of the temperature distribution inside the tissues was carried out by means of a numerical solution of the heat conduction equation. Experimental modeling was carried out on phantoms of biological tissues simulating their scattering properties as well as accumulation of the investigated nanoparticles doped with Nd

Indexed as

Cold TemperatureHyperthermia, InducedLaser TherapyModels, TheoreticalLuminescenceMonte Carlo MethodNanoparticlesNeodymiumNeoplasmsOptical DevicesPhantoms, ImagingNeodymiumDeep biotissue thermal monitoringLaser interstitial thermal therapyNd3+-doped nanoparticlesNear-infrared

Identifiers

PMID30762195

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.