Evidence map›Paper›PMID 30762178›Full record

ReviewCurrent heart failure reports2019

Diuretic Resistance in Heart Failure.

Richa Gupta, Jeffrey Testani, Sean Collins

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current heart failure reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 5 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 5 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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  5. The value of urinary sodium assessment in acute heart failure.European heart journal. Acute cardiovascular care · 2021
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  10. Spot urinary sodium in acute decompensation of advanced heart failure and dilutional hyponatremia: insights from DRAIN trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Richa GuptaDepartment of Cardiovascular Medicine, Vanderbilt University Medical Center, 1121 Medical Center Dr., Nashville, TN, 37212, USA.
Jeffrey TestaniDepartment of Cardiovascular Medicine, Yale Medical Center, PO Box 208017, New Haven, CT, 06520, USA.
Sean CollinsDepartment of Emergency Medicine, Vanderbilt University Medical Center, 1313 21st Ave. S, 703 Oxford House, Nashville, TN, 37232, USA. sean.collins@vumc.org.
Vanderbilt University Medical Center · USYale Cancer Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Using Short Stay Units (SSU) Instead of Routine Admission to Improve Patient Centered Health Outcomes for Acute Heart Failure (AHF) Patients.R01HS025411 · AHRQ · INDIANA UNIVERSITY INDIANAPOLIS · PI PANG, PETER S · 2017 to 2020
$1.4M
B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure (BLUSHED-AHF)R34HL136986 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI PANG, PETER S · 2017 to 2018
$758k
AHRQ HHS R01 HS025411NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R34 HL136986
6 · The paper itself

Abstract

purpose of reviewDiuretic resistance (DR) occurs along a spectrum of relative severity and contributes to worsening of acute heart failure (AHF) during an inpatient stay. This review gives an overview of mechanisms of DR with a focus on loop diuretics and summarizes the current literature regarding the prognostic value of diuretic efficiency and predictors of natriuretic response in AHF. RECENT

findingsThe pharmacokinetics of diuretics are impaired in chronic heart failure, but little is known about mechanisms of DR in AHF. Almost all diuresis after administration of a loop diuretic dose occurs in the first few hours after administration and within-dose DR can develop. Recent studies suggest that DR at the level of the nephron may be more important than defects in diuretic delivery to the tubule. Because loop diuretics induce natriuresis, urine sodium (UNa) concentration may serve as a functional, physiological, and direct measure for diuretic responsiveness to a given loop diuretic dose. Identifying and targeting individuals with DR for more aggressive, tailored therapy represents an important opportunity to improve outcomes. A better understanding of the mechanistic underpinnings of DR in AHF is needed to identify additional biomarkers and guide future trials and therapies.

Indexed as

DiureticsDrug ResistanceHeart FailureHumansNephronsPrognosisSodiumSodium Potassium Chloride Symporter InhibitorsDiureticsSodiumSodium Potassium Chloride Symporter InhibitorsAcute heart failureBiomarkersDiuretic resistanceLoop diureticsSpot urine sodium

Identifiers

PMID30762178
PMCPMC6431570
OpenAlexW2911792351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.