ArticleSleep & breathing = Schlaf & Atmung2019
The reduction of apnea-hypopnea duration ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in a rat model of obstructive sleep apnea.
Article in Sleep & breathing = Schlaf & Atmung, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- The dose-effect and clinical prediction of the longest apnea duration driving the decrease of blood oxygen: a large sample OSA study with 34-second and 52-second cut-off values was established.Frontiers in physiology · 2025Article
- Distribution characteristics of intestinal flora in patients with OSAHS and the relationship between different intestinal flora and sleep disorders, hypoxemia and obesity.Sleep & breathing = Schlaf & Atmung · 2024Article
- High prevalence of sleep-disordered breathing in the intensive care unit - a cross-sectional study.Sleep & breathing = Schlaf & Atmung · 2023Article
- Advances in animal models of obstructive sleep apnea.Frontiers in medicine · 2023Review
- Association Between Sleep Quality and Hypertension in Chinese Adults: A Cross-Sectional Analysis in the Tianning Cohort.Nature and science of sleep · 2022Article
- Cardiometabolic comorbidities in obstructive sleep apnea patients are related to disease severity, nocturnal hypoxemia, and decreased sleep quality.Respiratory research · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWe aimed to investigate the effect of obstructive sleep apnea (OSA) and apnea-hypopnea duration on endothelial, ventricular function, blood pressure, and inflammation in a rat model.
methodsWe established a novel rat model of OSA. Wistar rats were randomized to six groups according to 4-week different treatments: (1) OSA (apnea for 60 s in a 90-s window of breathing [60 s/90 s] with anesthesia), (2) OSA 30 s/90 s with anesthesia, (3) partial recovery (60 s/90 s for 2 weeks, followed by 15 s/90 s for 2 weeks with anesthesia), (4) complete recovery (60 s/90 s for 2 weeks with anesthesia, and then normal breathing for 2 weeks), (5) sham (normal breathing in the device with anesthesia), and (6) control group (normal breathing, normal cage, no anesthesia). We recorded blood pressure, endothelial function, left ventricular function, and inflammation at different time points.
resultsVascular inflammation and endothelial dysfunction occurred in OSA models. More systemic inflammatory and endothelial dysfunction were observed in longer apnea-hypopnea duration group and they were reversed in both partial and complete recovery groups. Left ventricular weight/body weight ratio was significantly higher in the OSA (60s/90s) group than complete recovery, sham, and control groups, which remained unchanged in partial recovery group (p < 0.05).
conclusionsLonger apnea-hypopnea duration is related to more systemic inflammatory and endothelial dysfunction, and hypertension and cardiac remodeling. These can be reversed after a period of recovery, which indicates that time parameters for assessing OSA, such as apnea-hypopnea duration, should be considered instead of apnea-hypopnea index only.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.