Evidence map›Paper›PMID 30762141›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Effects of live music during chemotherapy in lymphoma patients: a randomized, controlled, multi-center trial.

Margrethe Langer Bro, Christoffer Johansen, Peter Vuust, Lisbeth Enggaard, Bodil Himmelstrup, Torben Mourits-Andersen, Peter Brown, Francesco d'Amore, Elisabeth Anne Wreford Andersen, Niels Abildgaard and 1 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effects of music intervention on anxiety, depression, and quality of life of cancer patients receiving chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  3. Pooled it
  4. Randomised controlled trial of music listening combined with progressive muscle relaxation for mood management in women receiving chemotherapy for cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  5. Trial
  6. The effect of two different types of music played to cancer patients during chemotherapy on anxiety, nausea, and satisfaction levels.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
  7. Trial
  8. The efficacy of live music for adolescent and young adult patients during hematopoietic stem cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Trial
  9. Trial
  10. Trial
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
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  19. Physical and nonphysical effects of weekly music therapy intervention on the condition of radiooncology patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Margrethe Langer BroThe Danish National Academy of Music, Odense, Denmark. mbro10@smksnet.dk.ORCID http://orcid.org/0000-0003-1291-0303
Christoffer JohansenUnit of Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark.
Peter VuustCenter for Music in the Brain, Institute of Clinical Medicine, Aarhus University and The Royal Academy of Music, Aarhus/Aalborg, Denmark.
Lisbeth EnggaardDepartment of Haematology, Herlev Hospital, Herlev, Denmark.
Bodil HimmelstrupDepartment of Haematology, Roskilde Hospital, Roskilde, Denmark.
Torben Mourits-AndersenDepartment of Haematology, Hospital of Southwest Denmark, Esbjerg, Denmark.
Peter BrownDepartment of Haematology, Rigshospitalet, Copenhagen, Denmark.
Francesco d'AmoreDepartment of Haematology, Aarhus University Hospital, Aarhus, Denmark.
Elisabeth Anne Wreford AndersenUnit of Statistics and Pharmacoepidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark.
Niels AbildgaardDepartment of Haematology, Odense University Hospital, Odense, Denmark.
Jeppe GramDepartment of Endocrinology, Hospital of Southwest Jutland, Esbjerg, Jutland, Denmark.

Funding

Aarhus Symphony Orchestra NoneCopenhagen Phil NoneFamilien Hede Nielsens Fond NoneHiFi-Klubben NoneJuhl-Soerensen A/S NoneKarola Joergensens Fond NoneRegion of Southern Denmark NoneRoche.dk NoneS?nderjyllands Symphony Orchestra NoneThe Danish Cancer Society Research Center NoneThe Danish National Academy of Music NoneThe Danish National Research Foundation DNRF 117The Hospital of Southwest Denmark None
6 · The paper itself

Abstract

purposeChemotherapy is associated with both somatic and psychological side effects. Music might ease these problems. Several randomized controlled trials have investigated the effect of music, but the results are inconclusive. We aimed to examine whether live or pre-recorded music listening decreases anxiety during chemotherapy in newly diagnosed lymphoma patients.

methodsA total of 143 patients with non-Hodgkin and Hodgkin lymphomas were randomly assigned into three groups receiving either 30 min of patient-preferred live music (n = 47), 30 min of patient-preferred pre-recorded music (n = 47), or standard care (n = 49) during up to five outpatient chemotherapy sessions. The primary endpoint was anxiety measured by the Spielberger's State Anxiety Inventory. Secondary endpoints included blood pressure, pulse rate, nausea and vomiting, serum catecholamine levels pre- and post-intervention to measure arousal levels, and health-related quality of life. The Musical Ability Test was used to link musical ability to the primary endpoint.

resultsWhen adjusting for age, sex, diagnosis, number of sessions, and baseline anxiety, the linear mixed model showed a borderline statistically significant reduction in the primary outcome anxiety in the live music group compared to standard care (7% (95% CI, - 14% to 0%, p = 0.05), while the effect of pre-recorded music was non-significant (5% (95% CI, - 12% to + 3%, p = 0.18). No intervention effects were seen in secondary outcomes.

conclusionOur findings suggest that patient-preferred live music reduces anxiety among patients with malignant lymphomas undergoing chemotherapy. Musical ability among this group of cancer patients seems not to be a determining factor for effect of music intervention.

Indexed as

AdultAgedAntineoplastic AgentsAnxietyBlood PressureFemaleHeart RateHumansLymphomaMaleMiddle AgedMusicMusic TherapyQuality of LifeAntineoplastic AgentsAnxietyCancerChemotherapyHodgkin lymphomaMusic interventionNon-Hodgkin lymphomaRCT

Identifiers

PMID30762141

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.