ArticleEuropean radiology2019
Comparison of CT angiography collaterals for predicting target perfusion profile and clinical outcome in patients with acute ischemic stroke.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 53 citations in OpenAlex.
- Analysis of the baseline multiphase computed tomographic angiography findings to predict clinical outcomes in patients with middle cerebral artery M1 occlusion treated with mechanical thrombectomy.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Article
- Comparison of AI-assisted quantitative collateral score and visual collateral score in stroke thrombectomy triage.Neuroradiology · 2026Article
- Optimization of image quality and diagnostic accuracy for vascular stenosis in computed tomography perfusion-reconstructed cerebral computed tomography angiography using deep learning reconstruction.Journal of clinical imaging science · 2026Article
- An interpretable machine learning model for predicting prognosis in acute ischemic stroke with large vessel occlusion.Frontiers in neurology · 2026Article
- Collateral Status Evaluation Using CT Angiography and Perfusion Source Images in Acute Stroke Patients.Brain sciences · 2025Article
- Assessment of collaterals on multiphase CTA in stroke patients with a large vessel occlusion: an interrater and intrarater agreement study.Neuroradiology · 2025Article
- Lipidomic analysis identifies long-chain acylcarnitine as a target for ischemic stroke.Journal of advanced research · 2024Article
- Colour-coded collateral and venous outflow patterns in estimating infarct progression and predicting functional independence for stroke patients in late time window.The British journal of radiology · 2024Article
- Application of emerging technologies in ischemic stroke: from clinical study to basic research.Frontiers in neurology · 2024Review
- The value of a deep learning image reconstruction algorithm in whole-brain computed tomography perfusion in patients with acute ischemic stroke.Quantitative imaging in medicine and surgery · 2023Article
- Computational modeling of multiscale collateral blood supply in a whole-brain-scale arterial network.PLoS computational biology · 2023Article
- Pivotal role of multiphase computed tomography angiography for collateral assessment in patients with acute ischemic stroke.La Radiologia medica · 2023Review
- CT Perfusion as a Predictor of the Final Infarct Volume in Patients with Tandem Occlusion.Journal of personalized medicine · 2023Article
- The Combination of Whole-Brain Features and Local-Lesion Features in DSC-PWI May Improve Ischemic Stroke Outcome Prediction.Life (Basel, Switzerland) · 2022Article
- FLAIR vascular hyperintensities predict functional outcome after endovascular thrombectomy in patients with large ischemic cores.European radiology · 2022Article
- Comparison of time consumption and success rate between CT angiography- and CT perfusion- based imaging assessment strategy for the patients with acute ischemic stroke.BMC medical imaging · 2022Article
- Diagnostic accuracy of using Alberta Stroke Program Early Computed Tomography Score on CT perfusion map to predict a target mismatch in patients with acute ischemic stroke.Neuroradiology · 2022Article
- RAPID CT Perfusion-Based Relative CBF Identifies Good Collateral Status Better Than Hypoperfusion Intensity Ratio, CBV-Index, and Time-to-Maximum in Anterior Circulation Stroke.AJNR. American journal of neuroradiology · 2022Article
- Role of diabetes in collateral status assessed in CT perfusion-derived dynamic CTA in anterior circulation stroke.Neuroradiology · 2022Article
- Preprocedural Imaging : A Review of Different Radiological Factors Affecting the Outcome of Thrombectomy.Clinical neuroradiology · 2022Review
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9 authors at 1 institution in 1 country.
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Abstract
objectivesTo compare collateral status on single-phase CT angiography (sCTA) and multiphase CT angiography (mCTA) and their ability to predict a target mismatch on CT perfusion (CTP) and clinical outcome in patients with acute ischemic stroke (AIS).
methodsSeventy-three AIS patients with stroke onset between 5 and 15 h or with unclear onset time and occlusions in the M1/M2 segment of the middle cerebral artery and/or intracranial internal carotid artery underwent head non-contrast CT and CTP. Simulated sCTA and mCTA were reconstructed from CTP data and were compared for collaterals assessment. The ability to predict target mismatch on CTP (an ischemic core < 70 ml, a mismatch ratio ≥ 1.8, and an absolute difference ≥ 15 ml) and 90-day modified Rankin Scale (mRS) score of 0-2 was compared between sCTA and mCTA by using receiver operating curve analysis.
resultssCTA underestimated the collateral status when compared with mCTA (p < 0.01). The ability of mCTA to predict target mismatch (AUC = 0.902, 95% confidence interval [CI] 0.809, 0.959) and clinical outcome (AUC = 0.771; 95% CI, 0.655, 0.864) was better than that of sCTA (p < 0.05 overall). A mCTA collateral score of > 3 best identified the target mismatch (sensitivity, 78.4%; specificity, 90.9%) and predicted 90-day mRS score of 0-2 (sensitivity, 84.8%; specificity, 69.4%).
conclusionsThe collaterals were better estimated by mCTA compared with sCTA. A mCTA collateral score of > 3 optimized the prediction of a target mismatch on CTP and a good clinical outcome in patients with AIS. KEY POINTS: • Collateral circulation is a key determinant of ischemic core and penumbra. Better collaterals are associated with smaller ischemic core volumes and larger mismatch ratios on CT perfusion. • The collaterals can be better estimated by multiphase CTA compared with single-phase CTA. • A collateral score of > 3 on multiphase CTA best identifies patients with target mismatch on CT perfusion and predicts 90-day mRS score of 0-2.
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