ArticlePediatric surgery international2019
Morphometric demonstration of portal vein stenosis and hepatic arterial medial hypertrophy in patients with biliary atresia.
Article in Pediatric surgery international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 17 citations in OpenAlex.
- The diagnostic value of ultra-microangiography for biliary atresia.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Enhanced lymphangiogenesis in the left lateral segment of a biopsied liver during portoenterostomy for biliary atresia.Pediatric surgery international · 2024Article
- Portal vein hypoplasia is present in patients with biliary atresia at the time of diagnosis.Journal of pediatric gastroenterology and nutrition · 2024Observational
- Lymphangiogenesis in the liver of biliary atresia.BMC gastroenterology · 2024Article
- Assessment of the utility of two-dimensional shear wave elastography and superb microvascular imaging in postoperative patients with biliary atresia.Pediatric surgery international · 2024Article
- Preoperative imaging findings to predict 2-year native liver survival after the Kasai procedure in patients with biliary atresia.European radiology · 2024Article
- Insight into microvascular adaptive alterations in the Glisson system of biliary atresia after Kasai portoenterostomy using X-ray phase-contrast CT.European radiology · 2023Article
- New insights in understanding biliary atresia from the perspectives on maternal microchimerism.Frontiers in pediatrics · 2022Article
- Microvascular proliferation of the portal vein branches in the liver of biliary atresia patients at Kasai operation is associated with a better long-term clinical outcome.Pediatric surgery international · 2019Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePortal hypertension in patients with biliary atresia (BA) is generally thought to result from portal vein (PV) narrowing secondary to hepatic fibrosis. To test the hypothesis, we morphometrically analyzed the PVs and hepatic arteries (HAs).
methodsMorphometrical analyses of 25 BA and 26 non-BA liver biopsy specimens from patients treated from 2000 to 2014. The total specimen area, the fibrotic portal area, vessel diameter and medial thickness of the HAs were measured.
resultsThe PV diameter in BA patients was significantly smaller than that in non-BA patients. In BA, the numbers of normal-sized PVs and capillaries were decreased and increased, respectively. The PV diameter was not significantly correlated with the degree of fibrosis. We newly found that medial hypertrophy and the HA diameter increased with the number of endothelial cells in BA. The PV diameter was not significantly correlated with the medial thickness and was positively correlated with the HA diameter in BA.
conclusionsThe narrowing of the PV is unlikely to occur secondarily to liver fibrosis. The medial hypertrophy of the HA is not correlated with the decrease in the PV blood flow. These findings seem to be unique to the primary vascular lesions of BA.
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