ReviewJournal of clinical hypertension (Greenwich, Conn.)2019
Constipation-induced pressor effects as triggers for cardiovascular events.
Review in Journal of clinical hypertension (Greenwich, Conn.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 3 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Association between constipation and risk of cardiovascular or all-cause mortality: a meta-analysis.Annals of medicine · 2025Pooled it
- Association between constipation and risk of stroke: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Efficacy and safety of Bifidobacterium quadruple viable tablets combined with mosapride citrate in the treatment of constipation in China: a systematic review and meta-analysis.BMC gastroenterology · 2023Pooled it
- Constipation and Incident Cardiovascular Disease: A Nationwide, Real-World Cohort Study.JACC. Asia · 2026Article
- Constipation: More Than a Quality-of-Life Issue.JACC. Asia · 2026Article
- The laxative efficacy of a mixed extract ofOpen veterinary journal · 2026Article
- Non-pharmacological Management of Fibrosing Interstitial Lung Diseases.Tuberculosis and respiratory diseases · 2026Article
- Effect of electroacupuncture versus prucalopride for ultra-severe chronic constipation: Secondary analysis of a randomized controlled trial.Integrative medicine research · 2026Article
- Efficacy and Mechanism of Synbiotics in Relieving Functional Constipation: Optimized by Generation Time.Nutrients · 2026Article
- The Actual Condition of Chronic Constipation in Real-World Clinical Settings and Its Impact on Various Aspects of Daily Life.Digestive diseases (Basel, Switzerland) · 2026Observational
- Association of Initial Laxative Strategy With Clinical Outcomes in Critically Ill Patients With Acute Myocardial Infarction: A Retrospective Cohort Study.Cardiovascular therapeutics · 2026Article
- Article
- The JSH Morning Hypertension Eradication Program Project.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Administration of polyethylene glycol in critically ill patients with acute myocardial infarction: a retrospective propensity score-matched cohort study.European journal of clinical pharmacology · 2025Article
- Impact of non-cardiovascular factors on cardiovascular death in acute decompensated heart failure: Enhancing predictive models with frailty and comorbid constipation-the Constipation and Frailty Augmented AHEAD score.Geriatrics & gerontology international · 2025Article
- Integrated Management of Constipation in Hypothyroidism: Evaluating Pharmacological and Non-Pharmacological Interventions.Nursing reports (Pavia, Italy) · 2025Article
- Cardiac arrest while using the toilet: not uncommon and associated with adverse resuscitation profile.Resuscitation plus · 2025Article
- Association between magnesium oxide use and readmission risk in patients with heart failure and constipation.Journal of pharmaceutical health care and sciences · 2025Article
- Association between blood lead levels and constipation in adults: insights from NHANES data (2005-2010).BMC gastroenterology · 2025Article
- Association between the dietary index of gut microbiota and abnormal bowel symptoms in U.S. adults: a cross-sectional study based on NHANES 2007-2010.BMC gastroenterology · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Constipation is associated with cardiovascular events. Changes to the intestinal microbiota by constipation can induce atherosclerosis, blood pressure rise, and cardiovascular events. Constipation increases with age and often coexists with cardiovascular risk factors. In addition, strain at stool causes blood pressure rise, which can trigger cardiovascular events such as congestive heart failure, arrhythmia, acute coronary disease, and aortic dissection. However, because cardiovascular medical research often focuses on more dramatic interventions, the risk from constipation can be overlooked. Physicians caring for patients with cardiovascular disease should acknowledge constipation and straining with it as important cardiovascular risk, and prematurely intervene to prevent it. The authors review and discuss the relationship between constipation and cardiovascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.