ArticleAnnals of surgical oncology2019
Is Breast-Conserving Therapy Appropriate for Male Breast Cancer Patients? A National Cancer Database Analysis.
Article in Annals of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Radiotherapy and surgery for male breast cancer a population analysis of survival by age and stage.Discover oncology · 2026Article
- Oncologic safety of prophylactic nipple-sparing mastectomy: Outcomes of 1,255 cases exceeding a 6-year median follow-up.Breast cancer research and treatment · 2026Article
- Current Perspectives on Non-Metastatic Male Breast Cancer: Genetics, Biology, and Treatment Advances: A Systematic Review.Cancers · 2025Review
- A case report of male breast cancer treated with breast-conserving surgery.International journal of surgery case reports · 2025Article
- Male Breast Cancer: Evaluating the Current Landscape of Diagnosis and Treatment.Breast cancer (Dove Medical Press) · 2025Review
- Implementation of Choosing WiselyAnnals of surgical oncology · 2024Article
- Trends and efficacy of omitting axillary lymph node dissection in early-stage male breast cancer with limited nodal involvement: A population-based cohort study.Cancer medicine · 2024Article
- Nationwide Analysis of Locoregional Management for Ductal Carcinoma In Situ in Males: An NCDB Analysis of the Surgical Approach to DCIS in Males.Annals of surgical oncology · 2024Article
- Male Breast Cancer: a Review on Diagnosis, Treatment, and Survivorship.Current oncology reports · 2024Review
- Male breast cancer: Report of two cases with bloody nipple discharge.Radiology case reports · 2023Article
- Male Breast Cancer Patient and Surgeon Experience: The Male WhySurg Study.Annals of surgical oncology · 2022Article
- Male triple negative axillary accessory breast cancer-a case report.Translational cancer research · 2022Article
- Male Breast Cancer: Treatment Trends, Reported Outcomes, and Suggested Recommendations.Cureus · 2021Review
- ASO Author Reflections: Deescalating Therapy for Older Men with Early Estrogen Receptor Positive Breast Cancer.Annals of surgical oncology · 2021Article
- The Role of Radiation Therapy in Addition to Lumpectomy and Hormone Therapy in Men 70 Years of Age and Older with Early Breast Cancer: A NCDB Analysis.Annals of surgical oncology · 2021Article
- Surgery for Men with Breast Cancer: Do the Same Data Still Apply?Annals of surgical oncology · 2020Article
- Living with Male Breast Cancer: A Qualitative Study of Men's Experiences and Care Needs.Breast care (Basel, Switzerland) · 2020Article
- ASO Author Reflections: Surgical Treatment for Male Breast Cancer in the Modern Era.Annals of surgical oncology · 2019Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCurrent treatment guidelines for male breast cancer are predominantly guided by female-only clinical trials. With scarce research, it is unclear whether breast-conserving therapy (BCT) is equivalent to mastectomy in men. We sought to compare overall survival (OS) among male breast cancer patients who underwent BCT versus mastectomy.
methodsWe performed a retrospective analysis of 8445 stage I-II (T1-2 N0-1 M0) male breast cancer patients from the National Cancer Database (2004-2014). Patients were grouped according to surgical and radiation therapy (RT). BCT was defined as partial mastectomy followed by RT. Multivariable and inverse probability of treatment-weighted (IPTW) Cox proportional hazards models were used to compare OS between treatment groups, controlling for demographic and clinicopathologic characteristics.
resultsMost patients underwent total mastectomy (61.2%), whereas 18.2% underwent BCT, 12.4% underwent total mastectomy with RT, and 8.2% underwent partial mastectomy alone. In multivariable and IPTW models, partial mastectomy alone, total mastectomy alone, and total mastectomy with RT were associated with worse OS compared with BCT (p < 0.001 all). Ten-year OS was 73.8% for BCT and 56.3, 58.0 and 56.3% for other treatment approaches. Older age, higher T/N stage, histological grade, and triple-negative receptor status were associated with poorer OS (p < 0.05). Subgroup analysis by stage demonstrated similar results.
conclusionsIn this national sample of male breast cancer patients, BCT was associated with greater survival. The underlying mechanisms of this association warrant further study, because more routine adoption of BCT in male breast cancer appears to translate into clinically meaningful improvements in survival.
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