Evidence map›Paper›PMID 30761137›Full record

ArticleFrontiers in immunology2019

Butyrate Attenuates Lung Inflammation by Negatively Modulating Th9 Cells.

Raquel de Souza Vieira, Angela Castoldi, Paulo José Basso, Meire Ioshie Hiyane, Niels Olsen Saraiva Câmara, Rafael Ribeiro Almeida

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Pooled it
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  12. The role of dietary fibre in lung inflammation: microbiota, metabolites, and immune crosstalk.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  13. Article
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  15. Article
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  18. Research advance in correlation between childhood asthma and gut microbiota.Frontiers in cellular and infection microbiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Raquel de Souza VieiraLaboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Angela CastoldiLaboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Paulo José BassoLaboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Meire Ioshie HiyaneLaboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Niels Olsen Saraiva CâmaraLaboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Rafael Ribeiro AlmeidaLaboratory of Transplantation Immunobiology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Th9 cells orchestrate allergic lung inflammation by promoting recruitment and activation of eosinophils and mast cells, and by stimulating epithelial mucus production, which is known to be mainly dependent on IL-9. These cells share developmental pathways with induced regulatory T cells that may determine the generation of one over the other subset. In fact, the FOXP3 transcription factor has been shown to bind

Indexed as

Adoptive TransferAnimalsAnti-Inflammatory AgentsButyratesCell DifferentiationDisease Models, AnimalEosinophilsForkhead Transcription FactorsInterleukin-13Interleukin-9MaleMiceMice, Inbred C57BLOvalbuminPneumoniaPropionatesAnti-Inflammatory AgentsButyratesForkhead Transcription FactorsFoxp3 protein, mouseInterleukin-13Interleukin-9OvalbuminPropionatesbutyrateeosinophilslung inflammationTh9 cellstregs

Identifiers

PMID30761137
PMCPMC6361737
OpenAlexW2913442468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.