Evidence map›Paper›PMID 30761001›Full record

ReviewFrontiers in pharmacology2019

Unraveling the Function of Lemur Tyrosine Kinase 2 Network.

Daniel F Cruz, Carlos M Farinha, Agnieszka Swiatecka-Urban

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. LMTK2 and CRB1 are two novel risk genes for Alzheimer's disease in Han Chinese.The journal of prevention of Alzheimer's disease · 2025
    Article
  5. LMTK2 switches on canonical TGF-β1 signaling in human bronchial epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Lemur Tyrosine Kinases and Prostate Cancer: A Literature Review.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Daniel F CruzBiosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Campo Grande, Portugal.
Carlos M FarinhaBiosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Campo Grande, Portugal.
Agnieszka Swiatecka-UrbanDepartment of Nephrology, Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.
Children's Hospital of Pittsburgh · USUniversity of Lisbon · PT

Funding

Translational StudiesP30DK072506 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALCORN, JOHN F · 2005 to 2017
$12.5M
Regulation of the Endocytic Trafficking of CFTRR01HL090767 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWIATECKA-URBAN, AGNIESZKA · 2008 to 2012
$2.2M
High-Throughput Screening for Dab2 Inhibitors as Stabilizers of CFTRR01DK104847 · NIDDK · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2018
$1.6M
Novel Pathways in TGF BETA SignalingR56HL127202 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWIATECKA-URBAN, AGNIESZKA · 2016 to 2016
$352k
NHLBI NIH HHS R56 HL127202NIDDK NIH HHS R01 DK104847
6 · The paper itself

Abstract

Lemur Tyrosine Kinase 2 (LMTK2) is a recently cloned transmembrane protein, actually a serine/threonine kinase named after the Madagascar primate lemur due to the long intracellular C-terminal tail. LMTK2 is relatively little known, compared to other kinases but its role has been increasingly recognized. Published data show that LMTK2 regulates key cellular events, including endocytic trafficking, nerve growth factor signaling, apoptosis, and Cl

Indexed as

kinaseLMTK2phosphorylationPP1signaling pathway

Identifiers

PMID30761001
PMCPMC6361741
OpenAlexW2914253416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.