Evidence map›Paper›PMID 30760977›Full record

ArticleFrontiers in neuroscience2019

The Tenets of Teneurin: Conserved Mechanisms Regulate Diverse Developmental Processes in the

Alison T DePew, Michael A Aimino, Timothy J Mosca

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Synaptic Development in Diverse Olfactory Neuron Classes Uses Distinct Temporal and Activity-Related Programs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  3. Improvements in operant memory ofFrontiers in behavioral neuroscience · 2023
    Article
  4. Review
  5. Review
  6. Uncovering the genetic blueprint of theProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Review
  8. Discovery of Teneurins.Frontiers in neuroscience · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alison T DePewDepartment of Neuroscience, Thomas Jefferson University, Philadelphia, PA, United States.
Michael A AiminoDepartment of Neuroscience, Thomas Jefferson University, Philadelphia, PA, United States.
Timothy J MoscaDepartment of Neuroscience, Thomas Jefferson University, Philadelphia, PA, United States.

Funding

The Development and Organization of Central Synapses in DrosophilaR00DC013059 · NIDCD · THOMAS JEFFERSON UNIVERSITY · PI MOSCA, TIMOTHY J. · 2017 to 2019
$741k
NIDCD NIH HHS R00 DC013059
6 · The paper itself

Abstract

To successfully integrate a neuron into a circuit, a myriad of developmental events must occur correctly and in the correct order. Neurons must be born and grow out toward a destination, responding to guidance cues to direct their path. Once arrived, each neuron must segregate to the correct sub-region before sorting through a milieu of incorrect partners to identify the correct partner with which they can connect. Finally, the neuron must make a synaptic connection with their correct partner; a connection that needs to be broadly maintained throughout the life of the animal while remaining responsive to modes of plasticity and pruning. Though many intricate molecular mechanisms have been discovered to regulate each step, recent work showed that a single family of proteins, the Teneurins, regulates a host of these developmental steps in

Indexed as

cytoskeletonDrosophilaNMJolfactionpartner matchingspectrinsynapse formationteneurin

Identifiers

PMID30760977
PMCPMC6363694

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.