Evidence map›Paper›PMID 30760973›Full record

ReviewFrontiers in neuroscience2019

Ketogenic Diet and Epilepsy: What We Know So Far.

Isabella D'Andrea Meira, Tayla Taynan Romão, Henrique Jannuzzelli Pires do Prado, Lia Theophilo Krüger, Maria Elisa Paiva Pires, Priscila Oliveira da Conceição

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05469997 (Ketogenic Diet Interventions in Parkinson's Disease), which is not on this map. Cited by 167 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 7 pooled it
24.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05469997 nacompletednot on this mapstarted 2023, after this paper: background citation

Ketogenic Diet Interventions in Parkinson's Disease: Safeguarding the Gut Microbiome

TypeinterventionalSponsorUniversity of British ColumbiaRan2023 to 2024Enrolled52ConditionsParkinson DiseaseArmsMediterranean-Ketogenic Diet, Mediterranean diet supplemented with medium-chain triglyceride oil
3 · Its place in the literature

Who cites it

167 citing papers in PubMed, 7 syntheses or guidelines pooled it, 359 citations in OpenAlex.

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107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Isabella D'Andrea MeiraEpilepsy Department, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Brazil.
Tayla Taynan RomãoNeurology Department, Federal Fluminense University, Rio de Janeiro, Brazil.
Henrique Jannuzzelli Pires do PradoEpilepsy Department, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Brazil.
Lia Theophilo KrügerEpilepsy Department, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Brazil.
Maria Elisa Paiva PiresEpilepsy Department, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Brazil.
Priscila Oliveira da ConceiçãoNeurology Department, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Instituto Estadual do Cérebro Paulo Niemeyer · BRUniversidade do Estado do Rio de Janeiro · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Ketogenic Diet (KD) is a modality of treatment used since the 1920s as a treatment for intractable epilepsy. It has been proposed as a dietary treatment that would produce similar benefits to fasting, which is already recorded in the Hippocratic collection. The KD has a high fat content (90%) and low protein and carbohydrate. Evidence shows that KD and its variants are a good alternative for non-surgical pharmacoresistant patients with epilepsy of any age, taking into account that the type of diet should be designed individually and that less-restrictive and more-palatable diets are usually better options for adults and adolescents. This review discusses the KD, including the possible mechanisms of action, applicability, side effects, and evidence for its efficacy, and for the more-palatable diets such as the Modified Atkins Diet (MAD) and the Low Glycemic Index Diet (LGID) in children and adults.

Indexed as

diet therapyketogenic dietlow glycemic indexmodified Atkins dietrefractory epilepsy

Identifiers

PMID30760973
PMCPMC6361831
OpenAlexW2912654638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.