Evidence map›Paper›PMID 30760938›Full record

ArticleIsrael journal of chemistry2017

Synthesis and Biochemical Evaluation of Biotinylated Conjugates of Largazole Analogues: Selective Class I Histone Deacetylase Inhibitors.

Le Zhao, Christine E Dunne, Dane J Clausen, Justin M Roberts, Joshiawa Paulk, Haining Liu, Olaf G Wiest, James E Bradner, Robert M Williams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Israel journal of chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Le ZhaoDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523 (USA).
Christine E DunneDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523 (USA).
Dane J ClausenDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523 (USA).
Justin M RobertsDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115 (USA).
Joshiawa PaulkDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115 (USA).
Haining LiuDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670 (USA).
Olaf G WiestDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556-5670 (USA).
James E BradnerDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115 (USA).
Robert M WilliamsDepartment of Chemistry, Colorado State University, Fort Collins, Colorado 80523 (USA).

Funding

Multiple Myeloma and Cancer Therapies via Largazole AnalogsR01CA152314 · NCI · COLORADO STATE UNIVERSITY · PI WILLIAMS, ROBERT MICHAEL · 2010 to 2014
$1.5M
Selective Inhibition of HDAC6 in Cancer TherapyK08CA128972 · NCI · DANA-FARBER CANCER INST · PI BRADNER, JAMES E · 2008 to 2012
$789k
NCI NIH HHS K08 CA128972NCI NIH HHS R01 CA152314Wellcome Trust
6 · The paper itself

Abstract

The synthesis of biotinylated conjugates of synthetic analogues of the potent and selective histone deacetylase (HDAC) inhibitor largazole is reported. The thiazole moiety of the parent compound's cap group was derivatized to allow the chemical conjugation to biotin. The derivatized largazole analogues were assayed across a panel of HDACs 1-9 and retained potent and selective inhibitory activity towards the class I HDAC isoforms. The biotinylated conjugate was further shown to pull down HDACs 1, 2, and 3.

Indexed as

biotincancerinhibitorslargazolepeptidomimetics

Identifiers

PMID30760938
PMCPMC6370329

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.