Evidence map›Paper›PMID 30760902›Full record

ReviewNature reviews. Microbiology2019

Bacteria and archaea on Earth and their abundance in biofilms.

Hans-Curt Flemming, Stefan Wuertz

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07482553 (Evaluation of the Antibiofilm Activity of Chitosan Nanoparticles Against Uropathogenic Escherichia Coli Isolated From Assiut University Hospitals), which is not on this map. Cited by 682 papers.

0numbers the graph read from it
0cells of the map it votes in
682citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07482553 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Antibiofilm Activity of Chitosan Nanoparticles Against Uropathogenic Escherichia Coli Isolated From Assiut University Hospitals

TypeobservationalSponsorAssiut UniversityRan2026 to 2027Enrolled60ConditionsUrinary Tract Infections (UTIs), Catheter-Associated Urinary Tract Infections (CAUTIs), Biofilm Formation by Uropathogenic Escherichia Coli (UPEC)Armschitosan nanoparticles
3 · Its place in the literature

Who cites it

682 citing papers in PubMed.

  1. Measure the Biofilm Formation of Salmonella Using Crystal Violet Assay.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Diversification of biofilm architecture among freshwaterApplied and environmental microbiology · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Diversity of biofilm architectures within the genusApplied and environmental microbiology · 2026
    Article
  15. A biofilm-derived peptide as an underwater adhesive.bioRxiv : the preprint server for biology · 2026
    Article
  16. Review
  17. Universal-BacMicrobiologyOpen · 2026
    Article
  18. Review
  19. Article
  20. Review

622 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Hans-Curt FlemmingSingapore Centre for Environmental Life Sciences Engineering (SCELSE), Singapore, Singapore. hc.flemming@uni-due.de.ORCID http://orcid.org/0000-0002-3670-9236
Stefan WuertzSingapore Centre for Environmental Life Sciences Engineering (SCELSE), Singapore, Singapore. swuertz@ntu.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofilms are a form of collective life with emergent properties that confer many advantages on their inhabitants, and they represent a much higher level of organization than single cells do. However, to date, no global analysis on biofilm abundance exists. We offer a critical discussion of the definition of biofilms and compile current estimates of global cell numbers in major microbial habitats, mindful of the associated uncertainty. Most bacteria and archaea on Earth (1.2 × 10

Indexed as

BacteriaBiofilmsEarth, PlanetArchaeaEcosystemGeologic SedimentsPhylogeny

Identifiers

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.