ArticleThe Journal of antibiotics2019
Synthesis and antibiotic activity of novel acylated phloroglucinol compounds against methicillin-resistant Staphylococcus aureus.
Article in The Journal of antibiotics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed.
- Antimicrobial and anti-biofilm activity of Hypericum brasiliense extract and its fractions on Staphylococcus of canine origin.Scientific reports · 2025Article
- Combinations ofAntibiotics (Basel, Switzerland) · 2024Article
- A Comparative Study of the Synthesis and Hydrolysis ofMolecules (Basel, Switzerland) · 2022Article
- A machine learning model trained on a high-throughput antibacterial screen increases the hit rate of drug discovery.PLoS computational biology · 2022Article
- Phloroglucinol Derivative Carbomer Hydrogel Accelerates MRSA-Infected Wounds' Healing.International journal of molecular sciences · 2022Article
- Seaweed-Derived Phlorotannins: A Review of Multiple Biological Roles and Action Mechanisms.Marine drugs · 2022Review
- In vitro antibiofilm activity of resveratrol against avian pathogenic Escherichia coli.BMC veterinary research · 2021Article
- Semi-synthesis of antibacterial dialkylresorcinol derivatives.The Journal of antibiotics · 2021Article
- Article
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Authors and funding
5 authors.
Funding
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Abstract
The rise in antibiotic resistance among pathogenic microorganisms has created an imbalance in the drugs available for treatment, in part due to the slow development of new antibiotics. Cystic fibrosis (CF) patients are highly susceptible to antibiotic-resistant pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). Phloroglucinols and related polyketide natural products have demonstrated antimicrobial activity against a number of Gram-positive bacteria including S. aureus. In this study, we investigated a series of acylated phloroglucinol derivatives to determine their potential as lead compounds for the design of novel therapeutics. To assess the activity of these compounds, we determined the minimum inhibitory and bactericidal concentration (MIC and MBC, respectively), the minimum biofilm inhibitory and biofilm eradication concentration (MBIC and MBEC, respectively), and evaluated hemolytic activity, as well as their interaction with clinically relevant antibiotics. Of the 12 compounds tested against MRSA and methicillin-susceptible strains, four showed MIC values ranging from 0.125 to 8 µg ml
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.