Evidence map›Paper›PMID 30760775›Full record

ArticleScientific reports2019

Argon reduces the pulmonary vascular tone in rats and humans by GABA-receptor activation.

Said Suleiman, Sergej Klassen, Ira Katz, Galina Balakirski, Julia Krabbe, Saskia von Stillfried, Svetlana Kintsler, Till Braunschweig, Aaron Babendreyer, Jan Spillner and 7 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Positive Effects of Argon Inhalation After Traumatic Brain Injury in Rats.International journal of molecular sciences · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Argon Attenuates Multiorgan Failure in Relation with HMGB1 Inhibition.International journal of molecular sciences · 2021
    Article
  12. Review
  13. Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports ExtendedAmerican journal of respiratory cell and molecular biology · 2020
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 2 countries.

Said SuleimanInstitute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.
Sergej KlassenInstitute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.
Ira KatzMedical Research & Development, Air Liquide Santé Internationale, Centre de Recherche Paris-Saclay, 78354, Jouy-en-Josas, France.
Galina BalakirskiInstitute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.
Julia KrabbeInstitute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.ORCID 0000-0003-4205-9783
Saskia von StillfriedInstitute of Pathology, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.
Svetlana KintslerInstitute of Pathology, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.
Till BraunschweigInstitute of Pathology, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.
Aaron BabendreyerInstitute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.
Jan SpillnerDepartment of Cardiac and Thoracic Surgery, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.
Sebastian KalverkampDepartment of Cardiac and Thoracic Surgery, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.
Thomas SchröderDepartment of Surgery, Luisenhospital Aachen, 52064, Aachen, Germany.
Manfred MoellerInstitute for Occupational, Social and Environmental Medicine, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.
Mark CoburnDepartment of Anaesthesiology, Medical Faculty RWTH Aachen, 52074, Aachen, Germany.
Stefan UhligInstitute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.
Christian MartinInstitute of Pharmacology and Toxicology, Medical Faculty RWTH-Aachen, 52074, Aachen, Germany.
Annette D RiegDepartment of Anaesthesiology, Medical Faculty RWTH Aachen, 52074, Aachen, Germany. arieg@ukaachen.de.ORCID 0000-0002-7043-5494
RWTH Aachen University · DEAir Liquide (France) · FRLuisenhospital Aachen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Argon exerts neuroprotection. Thus, it might improve patients' neurological outcome after cerebral disorders or cardiopulmonary resuscitation. However, limited data are available concerning its effect on pulmonary vessel and airways. We used rat isolated perfused lungs (IPL) and precision-cut lung slices (PCLS) of rats and humans to assess this topic. IPL: Airway and perfusion parameters, oedema formation and the pulmonary capillary pressure (P

Indexed as

AnimalsArgonBaclofenBlood PressureEdemaEndothelin-1FemaleGABA-B Receptor AgonistsHemodynamicsHumansLungMuscle ContractionPulmonary ArteryRatsRats, WistarReceptors, GABA-BArgonBaclofenEndothelin-1GABA-B Receptor AgonistsReceptors, GABA-B

Identifiers

PMID30760775
PMCPMC6374423
OpenAlexW2914788709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.