ArticleScientific reports2019
Antitumor potential of new low molecular weight antioxidative preparations from the white rot fungus Cerrena unicolor against human colon cancer cells.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
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- Modern Pro-Health Applications of Medicinal Mushrooms: Insights into theMolecules (Basel, Switzerland) · 2025Review
- Characterization of Polysaccharide Extracts of Four Edible Mushrooms and Determination ofACS omega · 2024Article
- Transcriptomic and metabolomic analysis unveils a negative effect of glutathione metabolism on laccase activity inMicrobiology spectrum · 2024Article
- Biologically active secondary metabolites from white-rot fungi.Frontiers in chemistry · 2024Review
- Macrofungi as Medicinal Resources in Uzbekistan: Biodiversity, Ethnomycology, and Ethnomedicinal Practices.Journal of fungi (Basel, Switzerland) · 2023Review
- Electric Cell-Substrate Impedance Sensing (ECIS) as a Convenient Tool to Assess the Potential of Low Molecular Fraction Derived from Medicinal FungusMolecules (Basel, Switzerland) · 2022Article
- Low-Molecular-Weight Secondary Metabolites from Fungi:Molecules (Basel, Switzerland) · 2022Article
- Genomic Studies of White-Rot FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Thromboelastometric Analysis of AnticancerBiomolecules · 2021Article
- Mycopharmaceuticals and Nutraceuticals: Promising Agents to Improve Human Well-Being and Life Quality.Journal of fungi (Basel, Switzerland) · 2021Review
- Recent findings on the role of fungal products in the treatment of cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Review
- Chemopreventive activity of bioactive fungal fractions isolated from milk-supplemented cultures of3 Biotech · 2021Article
- Medicinal potential of mycelium and fruiting bodies of an arboreal mushroom Fomitopsis officinalis in therapy of lifestyle diseases.Scientific reports · 2020Article
- Lighting Conditions Influence the Dynamics of Protease Synthesis and Proteasomal Activity in the White Rot FungusBiomolecules · 2020Article
- Article
- Mushrooms-Rich Preparations on Wound Healing: From Nutritional to Medicinal Attributes.Frontiers in pharmacology · 2020Review
- Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the anticancer and antioxidant activities of low molecular weight subfractions isolated from secondary metabolites produced by the wood degrading fungus Cerrena unicolor. Human colon cancer cells (stage I) HT-29 and human normal colon epithelial cells CCD 841 CoTr were used in the research. The present study demonstrated that the low molecular weight subfractions exhibited inhibitory activity towards human colon cancer cells HT-29 at a concentration range of 25-200 μg/mL. All 6 subfractions inhibited proliferation of cells down to 47.5-9.2% at the highest concentrations in a dose-dependent manner. The most desired activity was exhibited by subfractions S, 3, 4, and 5, as the proliferation of HT-29 cells was inhibited to the greatest extent (16.5, 47.5, 42.7, and 26.1% of the control, respectively), while the effect on CCD 841 CoTr cells was the mildest (inhibition to 54.4, 71.4, 79.4, and 53.4%, compared to the control, respectively). The microscopic observation revealed that all extracts induced programmed cell death, i.e. apoptosis (up to 44.4% (subfraction 6) towards HT-29 and less than 20% (most fractions) towards CCD 841 CoTr), with no or a significantly low level of necrosis in both cell lines at the same time.
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