ArticleScientific reports2019
Sex Difference in the Association between High-sensitivity C-reactive Protein and Depression: The 2016 Korea National Health and Nutrition Examination Survey.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Pioglitazone Metformin Complex Improves Polycystic Ovary Syndrome Comorbid Psychological Distress via Inhibiting NLRP3 Inflammasome Activation: A Prospective Clinical Study.Mediators of inflammation · 2020Trial
- Associations of Depressive Symptom Severity with High-Sensitivity C-Reactive Protein Among U.S. Adults: NHANES 2015-2018.Journal of clinical medicine · 2026Article
- Socioeconomic Status Is Associated With Reward Processing, Interleukin 1β, Striatal Connectivity, and Antidepressant Outcomes in Individuals With Major Depressive Disorder: A CAN-BIND-1 Report.Biological psychiatry global open science · 2026Article
- Sex-specific associations between levels of high-sensitivity C-reactive protein and severity of depression: retrospective cross-sectional analysis of inpatients in China.BMC psychiatry · 2024Article
- Association between hs-CRP and depressive symptoms: a cross-sectional study.Frontiers in psychiatry · 2024Article
- Exploring the multiverse: the impact of researchers' analytic decisions on relationships between depression and inflammatory markers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Lack of bidirectional association between C-reactive protein and depressive symptoms in middle-aged and older adults: Results from a nationally representative prospective cohort study.Frontiers in psychology · 2023Article
- PTSD, Immune System, and Inflammation.Advances in experimental medicine and biology · 2023Article
- Psychiatric symptoms are not associated with circulating CRP concentrations after controlling for medical, social, and demographic factors.Translational psychiatry · 2022Article
- C-Reactive Protein: Marker of risk for post-traumatic stress disorder and its potential for a mechanistic role in trauma response and recovery.The European journal of neuroscience · 2022Review
- C-Reactive Protein as a Biomarker for Major Depressive Disorder?International journal of molecular sciences · 2022Review
- The association between serum microbial DNA composition and symptoms of depression and anxiety in mood disorders.Scientific reports · 2021Article
- Article
- Association between the severity of new-onset depression and unmet healthcare needs of South Korean adults.PloS one · 2021Article
- Sex differences in the association between self-rated health and high-sensitivity C-reactive protein levels in Koreans: a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey.Health and quality of life outcomes · 2020Article
- Cigarette type or smoking history: Which has a greater impact on the metabolic syndrome and its components?Scientific reports · 2020Article
- Serum Vitamin D Concentrations Are Associated With Depressive Symptoms in Men: The Sixth Korea National Health and Nutrition Examination Survey 2014.Frontiers in psychiatry · 2020Article
- A cross-sectional study on serum high-sensitivity C-reactive protein level and shift work among reproductive age women.Caspian journal of internal medicine · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevated levels of circulating high-sensitivity C-reactive protein (hs-CRP) have been observed in depression, with the body mass index (BMI) being a major mediator of this association. However, the sex difference in the association between hs-CRP and depression remains unclear. This study aimed to investigate the sex difference in the association between hs-CRP and depression. Data from the 2016 Korea National Health and Nutritional Examination Survey were used for our study. High hs-CRP was defined as >3.0 mg/L, while depression was determined using a cut-off score of 10 in the Patient Health Questionnaire-9. The study population comprised 5,483 Korean adults. Men with high hs-CRP levels showed statistically higher prevalence of depression than those with low hs-CRP levels (8.90% vs. 3.65%, P < 0.0001). The high hs-CRP group was 1.86 times more likely to have depression after adjusting for BMI and other covariates in men (adjusted odds ratio: 1.86; 95% confidence interval: 1.07-3.25; P = 0.029). Meanwhile, no statistically significant association between hs-CRP and depression was found among women. Depression was considerably associated with hs-CRP only in men, indicating a biological difference between men and women that can independently modify the relationship between hs-CRP and depression.
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