ArticleScientific reports2019
A mechanical method of cerebral cortical folding development based on thermal expansion.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 10 citations in OpenAlex.
- Article
- Mechanical hierarchy in the formation and modulation of cortical folding patterns.Scientific reports · 2023Article
- Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates.Developmental cognitive neuroscience · 2023Review
- The fractal brain: scale-invariance in structure and dynamics.Cerebral cortex (New York, N.Y. : 1991) · 2023Review
- How growth-induced stresses guide shape changes during animal morphogenesis: Mechanisms and implications.Seminars in cell & developmental biologyReview
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3 authors at 1 institution in 1 country.
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Abstract
Cortical folding malformations are associated with several severe neurological disorders, including epilepsy, schizophrenia and autism. However, the mechanism behind cerebral cortical folding development is not yet clear. In this paper, we propose a mechanical method based on thermal expansion to simulate the development of human cerebral cortical folding. The influences of stiffness ratio, growth rate ratio, and initial cortical plate thickness on cortical folding are discussed. The results of our thermal expansion model are consistent with previous studies, indicating that abnormal values of the aforementioned three factors could directly lead to cortical folding malformation in a generally fixed pattern.
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