ArticleScientific reports2019
Precise Slow Oscillation-Spindle Coupling Promotes Memory Consolidation in Younger and Older Adults.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.
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Who cites it
120 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Trial
- Sleep EEG oscillations and synaptic plasticity in memory consolidation across NREM and REM sleep.Dialogues in clinical neuroscience · 2027Review
- Article
- Article
- Propofol-Facilitated Recovery Sleep Modulates Cognitive Function via Slow Oscillation-Spindle Coupling After Acute Sleep Deprivation in Rats.CNS neuroscience & therapeutics · 2026Article
- A soft wearable near-infrared spectroscopy system for detecting brain water dynamics linked to glymphatic activity during sleep.Science advances · 2026Article
- Differential Nap-To-Nap Stability of Sleep Spindles, Slow Waves, and their Temporal Coupling: An Exploratory Study.Journal of sleep research · 2026Article
- Longitudinal Alterations in Sleep EEG Biomarkers of Memory Consolidation in Middle-Aged and Older Adults.bioRxiv : the preprint server for biology · 2026Article
- Deep sleep slow wave-spindle coupling is selectively linked to plasma amyloid-β levels in older adults in clinical trials.Scientific reports · 2026Article
- Dream content and slow waves benefit prey against predator in a video game confrontation.Scientific reports · 2026Article
- Auditory-evoked changes in slow oscillations and spindles correlate with memory consolidation in children with epilepsy and controls.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Modulating sleep: slow oscillation and spindle stimulation effects on physiology and memory.NPJ science of learning · 2026Article
- Differences in sleep spindles and polysomnography in humans: a meta-analysis on the influence of age, sex, and cognitive ability.Frontiers in sleep · 2026Review
- Sleep spindles are linked to white matter connectivity differentially in older adults with and without cognitive impairment.Brain communications · 2026Article
- Sleep in Lennox-Gastaut Syndrome: A Scoping Review.Children (Basel, Switzerland) · 2025Review
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
- Sleep in neurodegenerative diseases: A focus on melatonin, melanin-concentrating hormone and orexin.Journal of neuroendocrinology · 2025Review
- Exploring Deep Magnetoencephalography via Thalamo-Cortical Sleep Spindles.Human brain mapping · 2025Article
- Dementia Risk and Machine Learning-Derived Brain Age Index from Sleep Electroencephalography: A Pooled Cohort Analysis of Over 7,000 Individuals Across Five Community Cohorts.medRxiv : the preprint server for health sciences · 2025Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory consolidation during sleep relies on the precisely timed interaction of rhythmic neural events. Here, we investigate differences in slow oscillations (SO; 0.5-1 Hz), sleep spindles (SP), and their coupling across the adult human lifespan and ask whether observed alterations relate to the ability to retain associative memories across sleep. We demonstrate that older adults do not show the fine-tuned coupling of fast SPs (12.5-16 Hz) to the SO peak present in younger adults but, instead, are characterized most by a slow SP power increase (9-12.5 Hz) at the end of the SO up-state. This slow SP power increase, typical for older adults, coincides with worse memory consolidation in young age already, whereas the tight precision of SO-fast SP coupling promotes memory consolidation across younger and older adults. Crucially, brain integrity in source regions of SO and SP generation, including the medial prefrontal cortex, thalamus, hippocampus and entorhinal cortex, reinforces this beneficial SO-SP coupling in old age. Our results reveal that cognitive functioning is not only determined by maintaining structural brain integrity across the adult lifespan, but also by the preservation of precisely timed neural interactions during sleep that enable the consolidation of declarative memories.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.