Evidence map›Paper›PMID 30760729›Full record

ArticleScientific reports2019

Aberrant expression of a stabilized β-catenin mutant in keratocytes inhibits mouse corneal epithelial stratification.

Lingling Zhang, Yen-Chiao Wang, Yuka Okada, Suohui Zhang, Matthew Anderson, Chia-Yang Liu, Yujin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lingling ZhangSchool of Optometry, Indiana University, Bloomington, IN, 47405, USA.
Yen-Chiao WangSchool of Optometry, Indiana University, Bloomington, IN, 47405, USA.
Yuka OkadaSchool of Optometry, Indiana University, Bloomington, IN, 47405, USA.
Suohui ZhangComprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, School of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Matthew AndersonSchool of Optometry, Indiana University, Bloomington, IN, 47405, USA.
Chia-Yang LiuSchool of Optometry, Indiana University, Bloomington, IN, 47405, USA. liuchia@iu.edeu.
Yujin ZhangSchool of Optometry, Indiana University, Bloomington, IN, 47405, USA. zhang512@iu.edu.
Indiana University Bloomington · USThe Ohio State University · USWakayama Medical University · JP

Funding

Mouse Model for Eyelid Disease: Congenital BlepharophimosisR01EY021501 · NEI · UNIVERSITY OF CINCINNATI · PI LIU, CHIA-YANG · 2011 to 2015
$1.9M
Preschool Vision Screening by Parental Risk Factor QuestionnaireR21EY023086 · NEI · UNIVERSITY OF HOUSTON · PI MANNY, RUTH E · 2013 to 2014
$380k
NEI NIH HHS R01 EY021501NEI NIH HHS R21 EY023086
6 · The paper itself

Abstract

We previously reported that genetic deletion of β-catenin in mouse corneal keratocytes resulted in precocious corneal epithelial stratification. In this study, to strengthen the notion that corneal keratocyte-derived Wnt/β-catenin signaling regulates corneal epithelial stratification during mouse development, we examined the consequence of conditional overexpression of a stabilized β-catenin mutant (Ctnnb1

Indexed as

Gene Expression RegulationMutationWnt Signaling PathwayAnimalsbeta CateninBone Morphogenetic Protein 4Epithelium, CornealKeratin-12Keratin-14KeratinocytesMiceMice, TransgenicPAX6 Transcription FactorProtein StabilityTrans-Activatorsbeta CateninBmp4 protein, mouseBone Morphogenetic Protein 4CTNNB1 protein, mouseKeratin-12Keratin-14KRT12 protein, mouseKrt14 protein, mousePax6 protein, mousePAX6 Transcription FactorTrans-ActivatorsTrp63 protein, mouse

Identifiers

PMID30760729
PMCPMC6374483
OpenAlexW2914779906

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.