ArticleJournal of immunology (Baltimore, Md. : 1950)2019
A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-κB Activity.
Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- The ubiquitin-editing enzyme A20 (TNFAIP3): mechanisms of activation, biological function, diseases and therapeutic targets.Molecular biomedicine · 2026Review
- The Role of Ubiquitination and Deubiquitination in the Pathogenesis of Acute Kidney Injury: Progress in Research.Biomedicines · 2025Review
- Article
- Molecular Signatures of Senescence in Periodontitis: Clinical Insights.Journal of dental research · 2024Article
- Recent Clinical Treatment and Basic Research on the Alveolar Bone.Biomedicines · 2023Review
- Geniposide protected against cerebral ischemic injury through the anti-inflammatory effect via the NF-κB signaling pathway.Translational neuroscience · 2023Article
- SGK1 negatively regulates inflammatory immune responses and protects against alveolar bone loss through modulation of TRAF3 activity.The Journal of biological chemistry · 2022Article
- Application of Ligature-Induced Periodontitis in Mice to Explore the Molecular Mechanism of Periodontal Disease.International journal of molecular sciences · 2021Review
- Expression of deubiquitinases in human gingiva and cultured human gingival fibroblasts.BMC oral health · 2021Article
- Quercetin Preserves Oral Cavity Health by Mitigating Inflammation and Microbial Dysbiosis.Frontiers in immunology · 2021Article
- Th17 Cells in Periodontitis and Its Regulation by A20.Frontiers in immunology · 2021Review
- A20 Establishes Negative Feedback With TRAF6/NF-κB and Attenuates Early Brain Injury After Experimental Subarachnoid Hemorrhage.Frontiers in immunology · 2021Article
- The Ubiquitin System and A20: Implications in Health and Disease.Journal of dental research · 2021Review
- JAK3 restrains inflammatory responses and protects against periodontal disease through Wnt3a signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- A20 Restricts Inflammatory Response and Desensitizes Gingival Keratinocytes to Apoptosis.Frontiers in immunology · 2020Article
- Decrease of miR-19b-3p in Brain Microvascular Endothelial Cells Attenuates MeningiticPathogens (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Deregulated immune response to a dysbiotic resident microflora within the oral cavity leads to chronic periodontal disease, local tissue destruction, and various systemic complications. To preserve tissue homeostasis, inflammatory signaling pathways involved in the progression of periodontitis must be tightly regulated. A20 (TNFAIP3), a ubiquitin-editing enzyme, has emerged as one of the key regulators of inflammation. Yet, the function of A20 in the oral mucosa and the biological pathways in which A20 mitigates periodontal inflammation remain elusive. Using a combination of in vivo and ex vivo disease models, we report in this study that A20 regulates inflammatory responses to a keystone oral bacterium,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.