ArticleScience translational medicine2019
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.
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Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 1 pooled it
19.8field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
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Who cites it
170 citing papers in PubMed, 1 synthesis or guideline pooled it, 285 citations in OpenAlex.
- Predicting IDH and ATRX mutations in gliomas from radiomic features with machine learning: a systematic review and meta-analysis.Frontiers in radiology · 2024Pooled it
- Heterogeneity in cancer: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Autophagy inhibition sensitizes radiotherapy responses in high-grade mutant IDH1 glioma.Nature communications · 2026Article
- A dual pronged approach to cancer immune exclusion: tumor-derived LAIR-1 simultaneously drives fibrosis and blocks immune recruitment in glioma.Research square · 2026Article
- Vorasidenib improves response to subsequent chemoradiation in a genetically engineered mouse model of IDH-mutant glioma.Science translational medicine · 2026Article
- Glioblastoma Subtypes Exhibit Distinct Migration Mechanics and Immune Responses.Cancer research communications · 2026Article
- Reprogramming the immune suppressive tumor microenvironment in glioma enhances the efficacy of immune-mediated gene therapy.Molecular therapy. Oncology · 2026Article
- IDH1-R132H enhances oncolytic HSV-1 therapy by facilitating viral entry and immune activation in glioma.Nature communications · 2026Article
- A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Current and emerging therapies in IDH-mutant glioma.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- The impact of CHEK2 status on radiosurgical outcomes in breast cancer brain metastases.Neurosurgical review · 2026Article
- IRF4 Enhances Radiosensitivity of Cervical Cancer by Inhibiting the PI3K/Akt/mTOR Pathway to Regulate Autophagy.Cancer science · 2026Article
- MIF-mediated reprogramming of myeloid lineage within the glioma tumor microenvironment impacts the efficacy of immune stimulatory gene therapy.bioRxiv : the preprint server for biology · 2026Article
- YBX1&YBX3 as novel targets to potentiate immune checkpoint blockade response in gliomas.Neuro-oncology · 2026Article
- Single-cell profiling of peripheral and local immune compartments reveal unique genotype-independent prognostic immune signatures across isocitrate dehydrogenase-stratified glioma.Neuro-oncology · 2026Article
- Prickle4 Drives Microenvironmental Remodeling and Resistance to Parp Inhibition in IDH-Mutant Glioma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Methylation-induced suppression of YAP/TAZ confers sensitivity to HDAC inhibitors in high-grade IDH mutant gliomas.JCI insight · 2025Article
- Targeting the crosstalk of metabolism reprogramming and replication stress: novel strategy to combat cancer.Medical oncology (Northwood, London, England) · 2025Review
- Proteomic Analysis Uncovers Enhanced Inflammatory Phenotype and Distinct Metabolic Changes in IDH1 Mutant Glioma Cells.International journal of molecular sciences · 2025Article
- UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
110 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 6 institutions in 1 country.
Felipe J NúñezDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4962-3642
Flor M MendezDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Padma KadiyalaDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Mahmoud S AlghamriDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8018-7674
Masha G SavelieffDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-5575-2494
Maria B Garcia-FabianiDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Santiago HaaseDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Carl KoschmannDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Anda-Alexandra CalinescuDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7641-1573
Neha KamranDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Meghna SaxenaDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Rohin PatelDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Stephen CarneyDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-7786-5158
Marissa Z GuoDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Marta EdwardsDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Mats LjungmanDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1553-6695
Tingting QinDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Maureen A SartorDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Rebecca TagettDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-8604-7683
Sriram VennetiDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9764-0423
Jacqueline Brosnan-CashmanDepartments of Pathology, Oncology and Urology, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0001-9579-2853
Alan MeekerDepartments of Pathology, Oncology and Urology, Johns Hopkins University, Baltimore, MD 21287, USA.
Vera GorbunovaDepartment of Biology, University of Rochester, Rochester, NY 14627, USA.ORCID 0000-0001-8979-0333
Lili ZhaoDepartment of Biostatistics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Daniel M KremerRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Li ZhangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0703-7506
Costas A LyssiotisRogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9309-6141
Lindsey JonesDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-9603-7366
Cameron J HertingDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322, USA.
James L RossDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322, USA.
Dolores HambardzumyanDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322, USA.
Shawn Hervey-JumperDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Maria E FigueroaDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Pedro R LowensteinDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA. mariacas@med.umich.edu pedrol@med.umich.edu.ORCID 0000-0002-8427-4409
Maria G CastroDepartment of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA. mariacas@med.umich.edu pedrol@med.umich.edu.ORCID 0000-0002-4962-3642
University of Michigan · USEmory University · USJohns Hopkins University · USUniversity of California, San Francisco · USUniversity of Miami · USUniversity of Rochester · US
Funding
The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2014 to 2026
$36.9MStrategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3MTRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1MStatistics and Bioinformatics Core - WangU24DK097153 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2012 to 2017
$10.1MTraining Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3MTraining Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6MThe role of SIRT6 posttranslational modifications in aging and genome stability. Supplement: Testing SIRT6 activators as potential Alzheimer's disease therapy.R01AG027237 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2006 to 2026
$6.2MUniversity of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1MOligodendrocyte-focused rAAV gene therapy strategies for Canavan disease and LeukodystrophiesR01NS076991 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Guangping Gao · 2012 to 2026
$5.7MTumor-Associated Macrophages in Vasogenic Cerebral Edema in Brain TumorsR01NS100864 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Dolores Hambardzumyan · 2017 to 2026
$5.4MGraduate Training in the Pharmacological StudiesT32GM008602 · NIGMS · EMORY UNIVERSITY · PI HALL, RANDY A. · 1996 to 2021
$5.1MImaging Guided Genomics of Malignant TransformationR01CA169316 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COSTELLO, JOSEPH F · 2013 to 2017
$3.0MNCI NIH HHS K08 CA181475NCI NIH HHS L30 CA188846NCI NIH HHS R01 CA158286NCI NIH HHS R01 CA169316NCI NIH HHS R01 CA172380NCI NIH HHS T32 CA009110NCI NIH HHS T32 CA009676NCI NIH HHS T32 CA151022NCI NIH HHS U01 CA224160NHGRI NIH HHS R01 HG006786NHLBI NIH HHS R01 HL126947NIA NIH HHS P01 AG047200NIA NIH HHS R01 AG027237NIBIB NIH HHS R01 EB022563NIDDK NIH HHS U24 DK097153NIEHS NIH HHS P30 ES017885NIGMS NIH HHS R25 GM086262NIGMS NIH HHS T32 GM008602NINDS NIH HHS F31 NS103500NINDS NIH HHS F31 NS106887NINDS NIH HHS K08 NS099427NINDS NIH HHS K08 NS110919NINDS NIH HHS R01 NS076991NINDS NIH HHS R01 NS082311NINDS NIH HHS R01 NS096756NINDS NIH HHS R01 NS100864NINDS NIH HHS R01 NS105556NINDS NIH HHS R21 NS106554NINDS NIH HHS R37 NS094804
Abstract
Patients with glioma whose tumors carry a mutation in isocitrate dehydrogenase 1 (IDH1
Indexed as
Epigenesis, GeneticAnimalsAtaxia Telangiectasia Mutated ProteinsBrain NeoplasmsCell DifferentiationDisease Models, AnimalDNA DamageDNA MethylationDNA RepairGene OntologyGenomeGliomaHistonesHumansIsocitrate DehydrogenaseMiceAtaxia Telangiectasia Mutated ProteinsHistonesIDH1 protein, humanIdh1 protein, mouseIsocitrate DehydrogenaseTumor Suppressor Proteins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.