Evidence map›Paper›PMID 30760575›Full record

ArticleJournal of virology2019

The IκB Kinases Restrict Human Cytomegalovirus Infection.

Christopher M Goodwin, Joshua Munger

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Tuning the Orchestra: HCMV vs. Innate Immunity.Frontiers in microbiology · 2020
    Review
  5. UJournal of virology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher M GoodwinDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA.
Joshua MungerDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA josh.munger@rochester.edu.
University of Rochester · US

Funding

Training Program in Oral ScienceT90DE021985 · NIDCR · UNIVERSITY OF ROCHESTER · PI OVITT, CATHERINE, YULE, DAVID I · 2011 to 2021
$5.6M
HCMV-mediated repurposing of AMPK & CaMKK signaling for productive infectionR01AI127370 · NIAID · UNIVERSITY OF ROCHESTER · PI MUNGER, JOSHUA C · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI127370NIDCR NIH HHS T90 DE021985
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes disease in immunosuppressed populations. HCMV has a complex relationship with innate immune signaling pathways. Specifically, HCMV has been found to block some aspects of inflammatory signaling while benefiting from others. Through analysis of knockout cell lines targeting the NF-κB regulatory kinases IκB kinase α (IKKα) and IKKβ, we find that the IKKs are host restriction factors that contribute to cytokine-mediated resistance to viral infection, limit the initiation of HCMV infection, and attenuate viral cell-to-cell spread. The HCMV U

Indexed as

Signal TransductionCytomegalovirusCytomegalovirus InfectionsHEK293 CellsHumansI-kappa B KinaseNF-kappa BViral ProteinsCHUK protein, humanI-kappa B KinaseIKBKB protein, humanNF-kappa BViral ProteinscytomegalovirusIKKinnate immunityNF-Kβ

Identifiers

PMID30760575
PMCPMC6475784
OpenAlexW2913684353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.