Evidence map›Paper›PMID 30760566›Full record

ArticleJournal of virology2019

Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants.

Mingkui Zhou, Michael Humbert, Muhammad M Mukhtar, Hanna B Scinto, Hemant K Vyas, Samir K Lakhashe, Siddappa N Byrareddy, Gregor Maurer, Swati Thorat, Joshua Owuor and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

Mingkui Zhou *Texas Biomedical Research Institute, San Antonio, Texas, USA.
Michael Humbert *Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Muhammad M Mukhtar *Texas Biomedical Research Institute, San Antonio, Texas, USA.
Hanna B Scinto *Texas Biomedical Research Institute, San Antonio, Texas, USA.
Hemant K VyasTexas Biomedical Research Institute, San Antonio, Texas, USA.
Samir K LakhasheTexas Biomedical Research Institute, San Antonio, Texas, USA.
Siddappa N ByrareddyDana-Farber Cancer Institute, Boston, Massachusetts, USA.
Gregor MaurerTexas Biomedical Research Institute, San Antonio, Texas, USA.
Swati ThoratDana-Farber Cancer Institute, Boston, Massachusetts, USA.
Joshua OwuorTexas Biomedical Research Institute, San Antonio, Texas, USA.
Zhao LaiGreehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Yidong ChenGreehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Anthony GriffithsTexas Biomedical Research Institute, San Antonio, Texas, USA.
Agnès-Laurence ChenineDana-Farber Cancer Institute, Boston, Massachusetts, USA.
Sanjeev GumberYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
François VillingerYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
David MontefioriDepartment of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
Ruth M RuprechtTexas Biomedical Research Institute, San Antonio, Texas, USA rruprecht@txbiomed.org.
Dana-Farber Cancer Institute · USTexas Biomedical Research Institute · USBiomedical Research Institute · USEmory University · USHarvard University · USThe University of Texas Health Science Center at San Antonio · USDuke University · USUniversity of Veterinary Medicine Vienna · AT

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Virology and ImmunologyP01AI048240 · NIAID · UNIVERSITY OF WASHINGTON · PI RUPRECHT, RUTH MARGRIT · 2000 to 2020
$46.7M
Infant Immunoprophylaxis against a Primate LentivirusR37AI034266 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI RUPRECHT, RUTH MARGRIT · 2003 to 2012
$7.7M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR000149 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A · 2012 to 2013
$6.8M
Functional cure and virus eradication by early HAART plus vaccination with live attenuated rubella virus vectors in macaque infants and neonatesR01AI118586 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI RUPRECHT, RUTH MARGRIT · 2015 to 2018
$5.0M
Humoral Correlates of Protection Against HIVR01AI100703 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI RUPRECHT, RUTH MARGRIT · 2012 to 2016
$4.0M
High Throughput DNA Sequencer: Illumina HiSeq 3000 SequencerS10OD021805 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2016 to 2016
$600k
NCATS NIH HHS UL1 TR000149NCI NIH HHS P30 CA054174NIAID NIH HHS P01 AI048240NIAID NIH HHS R01 AI100703NIAID NIH HHS R01 AI118586NIAID NIH HHS R37 AI034266NIH HHS P51 OD011132NIH HHS P51 OD011133NIH HHS S10 OD021805
6 · The paper itself

Abstract

Simian-human immunodeficiency virus (SHIV) infection in rhesus macaques (RMs) resembles human immunodeficiency virus type 1 (HIV-1) infection in humans and serves as a tool to evaluate candidate AIDS vaccines. HIV-1 clade A (HIV-A) predominates in parts of Africa. We constructed an R5 clade A SHIV (SHIV-A; strain SHIV-KNH1144) carrying

Indexed as

Adaptive ImmunityMutationAnimalsenv Gene Products, Human Immunodeficiency VirusHIV-1HIV InfectionsHumansLeukocytes, MononuclearMacaca mulattaSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusVirus Replicationenv Gene Products, Human Immunodeficiency VirusadaptationHIVimmunodepletionrhesus macaquesSHIVSHIV-A

Identifiers

PMID30760566
PMCPMC6475780
OpenAlexW2912295684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.