Evidence map›Paper›PMID 30760332›Full record

ArticleTrials2019

Study of negative pressure wound therapy as an adjunct treatment for acute burns in children (SONATA in C): protocol for a randomised controlled trial.

Cody C Frear, Bronwyn Griffin, Leila Cuttle, Steven M McPhail, Roy Kimble

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Cody C FrearCentre for Children's Burns and Trauma Research, Level 7, Children's Health Research Center, The University of Queensland, 62 Graham St., South Brisbane, QLD, 4101, Australia. cody.frear@uqconnect.edu.au.ORCID http://orcid.org/0000-0002-6011-2472
Bronwyn GriffinCentre for Children's Burns and Trauma Research, Level 7, Children's Health Research Center, The University of Queensland, 62 Graham St., South Brisbane, QLD, 4101, Australia.
Leila CuttleInstitute of Health and Biomedical Innovation, Centre for Children's Burns and Trauma Research, Lvl 8, Children's Health Research Centre, Queensland University of Technology, South Brisbane, QLD, 4101, Australia.
Steven M McPhailCentre for Functioning and Health Research, Metro South Health, Queensland Health, Brisbane, QLD, 4102, Australia.
Roy KimbleCentre for Children's Burns and Trauma Research, Level 7, Children's Health Research Center, The University of Queensland, 62 Graham St., South Brisbane, QLD, 4101, Australia.
Children's Medical Research Institute · AUQueensland Health · AUQueensland University of Technology · AU

Funding

Smith and Nephew 1800000028
6 · The paper itself

Abstract

backgroundAlthough negative pressure wound therapy (NPWT) is widely used in the management of several wound types, its efficacy as a primary therapy for acute burns has not yet been adequately investigated, with research in the paediatric population particularly lacking. There is limited evidence, however, that NPWT might benefit children with burns, amongst whom scar formation, wound progression and pain continue to present major management challenges. The purpose of this trial is to determine whether NPWT in conjunction with standard therapy accelerates healing, reduces wound progression and decreases pain more effectively than standard treatment alone. METHODS/

designA total of 104 children will be recruited for this trial. To be eligible, candidates must be under 17 years of age and present to the participating children's hospital within 7 days of their injury with a thermal burn covering <5% of their total body surface area. Facial and trivial burns will be excluded. Following a randomised controlled parallel design, participants will be allocated to either an active control or intervention group. The former will receive standard therapy consisting of Acticoat™ and Mepitel™. The intervention arm will be treated with silver-impregnated dressings in addition to NPWT via the RENASYS TOUCH™ vacuum pump. Participants' dressings will be changed every 3 to 5 days until their wounds are fully re-epithelialised. Time to re-epithelialisation will be studied as the primary outcome. Secondary outcomes will include pain, pruritus, wound progression, health-care-resource use (and costs), ease of management, treatment satisfaction and adverse events. Wound fluid collected during NPWT will also be analysed to generate a proteomic profile of the burn microenvironment. DISCUSSION: The study will be the first randomised controlled trial to explore the clinical effects of NPWT on paediatric burns, with the aim of determining whether the therapy warrants implementation as an adjunct to standard burns management.

trial registrationAustralian New Zealand Clinical Trials Registry, ACTRN12618000256279 . Registered on 16 February 2018.

Indexed as

Randomized Controlled Trials as TopicAcute DiseaseAdolescentBurnsChildChild, PreschoolEpitheliumHumansInfantInfant, NewbornNegative-Pressure Wound TherapyOutcome Assessment, Health CareRegenerationPaediatric, Burns, Negative-pressure Wound Therapy, Re-epithelialisation, Pain, Burn wound progression, Itch, Randomised controlled trial

Identifiers

PMID30760332
PMCPMC6374905
OpenAlexW2921826096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.