Evidence map›Paper›PMID 30760274›Full record

SynthesisWorld journal of surgical oncology2019

Transperineal versus transrectal prostate biopsy in the diagnosis of prostate cancer: a systematic review and meta-analysis.

Jianjian Xiang, Huaqing Yan, Jiangfeng Li, Xiao Wang, Hong Chen, Xiangyi Zheng

Registry-linked trialAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04081636 (Prospective, Randomized Study Comparing Transperineal and Transrectal Prostate Biopsy Efficacy and Complications), which is not on this map. Cited by 156 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04081636 nacompletednot on this map

Prospective, Randomized Study Comparing Transperineal and Transrectal Prostate Biopsy Efficacy and Complications (ProBE-PC Trial)

TypeinterventionalSponsorAlbany Medical CollegeRan2019 to 2024Enrolled840ConditionsProstate Cancer, PSA, InfectionArmsSystematic Transrectal biopsy (TR-Bx), Targeted Transrectal biopsy (TR-Bx), Systematic Transperineal biopsy (TP-Bx), Targeted Transperineal biopsy (TP-Bx)
3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  8. Ultrasound-Guided Transperineal Versus Transrectal Prostate Aspiration Biopsy in Diagnosing Prostate Cancer: An Observational Comparison Study.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jianjian XiangDepartment of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Huaqing YanDepartment of Urology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Jiangfeng LiDepartment of Urology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Xiao WangDepartment of Urology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Hong ChenDepartment of Urology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. 10918090@zju.edu.cn.
Xiangyi ZhengDepartment of Urology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. zheng_xy@zju.edu.cn.

Funding

China Postdoctoral Science Foundation Grant 2018M632489National Natural Science Foundation of China 81472375National Natural Science Foundation of China 81802564
6 · The paper itself

Abstract

backgroundBecause conventional prostate biopsy has some limitations, optimal variations of prostate biopsy strategies have emerged to improve the diagnosis rate of prostate cancer. We conducted the systematic review to compare the diagnosis rate and complications of transperineal versus transrectal prostate biopsy. We searched for online publications published through June 27, 2018, in PubMed, Scopus, Web of Science, and Chinese National Knowledge Infrastructure databases. The relative risk and 95% confidence interval were utilized to appraise the diagnosis and complication rate. The condensed relative risk of 11 included studies indicated that transperineal prostate biopsy has the same diagnosis accuracy of transrectal prostate biopsy; however, a significantly lower risk of fever and rectal bleeding was reported for transperineal prostate biopsy. No clue of publication bias could be identified. SHORT

conclusionTo conclude, this review indicated that transperineal and transrectal prostate biopsy have the same diagnosis accuracy, but the transperineal approach has a lower risk of fever and rectal bleeding. More studies are warranted to confirm these findings and discover a more effective diagnosis method for prostate cancer.

Indexed as

Biopsy, Large-Core NeedleFeverGastrointestinal HemorrhageHumansMalePerineumPostoperative ComplicationsPrognosisProstateProstatic NeoplasmsRectumUltrasonography, InterventionalComplicationDiagnosis accuracyProstate biopsyTransperinealTransrectal

Identifiers

PMID30760274
PMCPMC6375152

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.