Evidence map›Paper›PMID 30760251›Full record

ArticleBMC nephrology2019

Improved long-term survival with home hemodialysis compared with institutional hemodialysis and peritoneal dialysis: a matched cohort study.

Helena Rydell, Kerstin Ivarsson, Martin Almquist, Mårten Segelmark, Naomi Clyne

Open access · goldAbstract readComparative StudyEvaluation Study
In one paragraph

Article in BMC nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Peritoneal dialysis versus haemodialysis for people commencing dialysis.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Home versus in-centre haemodialysis for people with kidney failure.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Article
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  9. Review
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  13. Similar survival on home haemodialysis and automated peritoneal dialysis: an inception cohort study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
    Article
  14. Review
  15. Assessing the efficacy of coproduction to better understand the barriers to achieving sustainability in NHS chronic kidney services and create alternate pathways.Health expectations : an international journal of public participation in health care and health policy · 2022
    Article
  16. Article
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  20. Optimization of Dialysis Modality Transitions for Improved Patient Care.Canadian journal of kidney health and disease · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Helena RydellDepartment of Clinical Sciences Lund, University, Skane University Hospital, Nephrology Lund, Lund, Sweden. Helena.rydell@sll.se.ORCID 0000-0003-1123-1835
Kerstin IvarssonDepartment of Clinical Sciences Lund, Pediatric psychiatry, Lund University, Skane University Hospital, Lund, Sweden.
Martin AlmquistDepartment of Clinical Sciences, Lund University, Skane University Hospital Lund Surgery, Lund, Sweden.
Mårten SegelmarkDepartment of Clinical Sciences Lund, University, Skane University Hospital, Nephrology Lund, Lund, Sweden.
Naomi ClyneDepartment of Clinical Sciences Lund, University, Skane University Hospital, Nephrology Lund, Lund, Sweden.
Lund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe survival rate for dialysis patients is poor. Previous studies have shown improved survival with home hemodialysis (HHD), but this could be due to patient selection, since HHD patients tend to be younger and healthier. The aim of the present study is to analyse the long-term effects of HHD on patient survival and on subsequent renal transplantation, compared with institutional hemodialysis (IHD) and peritoneal dialysis (PD), taking age and comorbidity into account.

methodsPatients starting HHD as initial renal replacement therapy (RRT) were matched with patients on IHD or PD, according to gender, age, Charlson Comorbidity Index and start date of RRT, using the Swedish Renal Registry from 1991 to 2012. Survival analyses were performed as intention-to-treat (disregarding changes in RRT) and per-protocol (as on initial RRT).

resultsA total of 152 patients with HHD as initial RRT were matched with 608 IHD and 456 PD patients, respectively. Median survival was longer for HHD in intention-to-treat analyses: 18.5 years compared with 11.9 for IHD (p <  0.001) and 15.0 for PD (p = 0.002). The difference remained significant in per-protocol analyses omitting the contribution of subsequent transplantation. Patients on HHD were more likely to receive a renal transplant compared with IHD and PD, although treatment modality did not affect subsequent graft survival (p > 0.05).

conclusionHHD as initial RRT showed improved long-term patient survival compared with IHD and PD. This survival advantage persisted after matching and adjusting for a higher transplantation rate. Dialysis modality had no impact on subsequent graft survival.

Indexed as

AdultAge DistributionCase-Control StudiesComorbidityConfounding Factors, EpidemiologicFemaleHemodialysis, HomeHemodialysis Units, HospitalHumansKaplan-Meier EstimateKidney Failure, ChronicKidney TransplantationMaleMiddle AgedPeritoneal DialysisRenal DialysisHome hemodialysisInstitutional hemodialysisPeritoneal dialysisRenal graft survivalSurvival

Identifiers

PMID30760251
PMCPMC6375181
OpenAlexW2947528455

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.