ArticleBMC ophthalmology2019
Migraine and increased risk of developing open angle glaucoma: a population-based cohort study.
Article in BMC ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Migraine and the risk of glaucoma: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Color Doppler Imaging Assessment of Ocular Blood Flow Following Ab Externo Canaloplasty in Primary Open-Angle Glaucoma.Journal of clinical medicine · 2024Article
- Eccentricity Dependency of Retinal Electrophysiological Deficits in People With Episodic Migraine.Investigative ophthalmology & visual science · 2024Article
- Increased late-onset glaucoma risk following vitrectomy for macular pucker or hole.Eye (London, England) · 2024Article
- Glaucoma and Systemic Disease.Life (Basel, Switzerland) · 2023Review
- Retinal microvasculature features in patients with migraine: a systematic review and meta-analysis.Frontiers in neurology · 2023Review
- Article
- Impact of Systemic Comorbidities on Ocular Hypertension and Open-Angle Glaucoma, in a Population from Spain and Portugal.Journal of clinical medicine · 2022Article
- Diabetes mellitus and incident glaucoma in Australia: a 10-year cohort study from the 45 and Up Study.Annals of translational medicine · 2022Article
- Predictors of Early Onset Glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Case report: Findings of automated perimetry during a migraine episode in a patient with glaucoma.Frontiers in medicine · 2022Article
- Air Pollutant Particles, PMInternational journal of environmental research and public health · 2021Article
- Oxidative Stress and the Role of NADPH Oxidase in Glaucoma.Antioxidants (Basel, Switzerland) · 2021Review
- Systemic and ocular determinants of mean ocular perfusion pressure in a population-based sample.Japanese journal of ophthalmology · 2020Article
- Primary Open Angle Glaucoma and Vascular Risk Factors: A Review of Population Based Studies from 1990 to 2019.Journal of clinical medicine · 2020Review
- Increased Incidence of Glaucoma in Sensorineural Hearing Loss: A Population-Based Cohort Study.International journal of environmental research and public health · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMigraine is linked to endothelial dysfunction and is considered to be a systemic vasculopathy. Interestingly, systemic vascular diseases also occur in glaucoma patients and are considered to be vascular risk factors. Whether migraine is simply a concomitant condition in glaucoma patients or a risk factor per se for glaucoma remains unknown. Thus, in the present study, we investigated the risk for open angle glaucoma (OAG) in migraineurs using a 10-year follow-up study that employed a nationwide population-based dataset in Taiwan.
methodsThis retrospective matched-cohort study used data sourced from the Longitudinal Health Insurance Database 2000. We included 17,283 subjects with migraine in the study cohort and randomly selected 69,132 subjects from the database for the comparison group. Each subject in this study was individually traced for a 10-year period to identify those subjects who subsequently received a diagnosis of OAG. The age-adjusted Charlson's comorbidity index (ACCI) score was utilized to compute the burden of comorbidity in each subject. Multivariate regression analysis was used to assess risk factors for OAG in migraineurs. Cox proportional hazards regression was performed to compare the 10-year risk of OAG between the migraineurs and the comparison cohort.
resultsMigraineurs had more vascular comorbidities than the comparison cohort. The overall incidence of OAG (per 1000 person-years) was 1.29 and 1.02, respectively, for migraineurs and the comparison cohort during the 10-year follow-up period. Age, hyperlipidemia, and diabetes mellitus were three significant risk factors for OAG in migraineurs. After adjusting for patients' age and vascular comorbidities, migraineurs were found to have a 1.68-fold (95% confidence interval [CI], 1.20-2.36) greater risk of developing OAG than the comparison cohort, in subjects with an ACCI score of 0. This association became statistically nonsignificant in subjects with ACCI scores of 1-2 or ≥ 3.
conclusionMigraine is associated with a higher risk of OAG for patients with no comorbidity who are aged under 50 years.
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