ArticleBMC infectious diseases2019
Epidemiologic study on changes in occurrence of hemorrhagic fever with renal syndrome in Republic of Korea for 17 years according to age group: 2001-2017.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The protective efficacy of inactivated vaccine against hemorrhagic fever with renal syndrome: A meta-analysis.Medicine · 2025Pooled it
- Broad-spectrum molecular detection of zoonotic agents in wild micromammals: a nationwide surveillance study in the Republic of Korea.Parasites & vectors · 2026Article
- Global threats and regional trends: Navigating the complex landscape of human orthohantavirus infections.Infectious diseases & immunity · 2026Review
- Clinical and laboratory factors associated with scrub typhus and hemorrhagic fever with renal syndrome in Southwestern Korea: A cross-sectional study.PLoS neglected tropical diseases · 2025Article
- Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China.Infectious diseases of poverty · 2025Article
- Analysis of Clinical and Laboratory Profiles of Patients Hospitalized with Hemorrhagic Fever with Renal Syndrome in Southwestern South Korea.The American journal of tropical medicine and hygiene · 2025Article
- Protocol to produce a systematic Arenavirus and Hantavirus host-pathogen database: Project ArHa.Wellcome open research · 2025Article
- Spatial-temporal drivers and incidence heterogeneity of hemorrhagic fever with renal syndrome transmission in Shandong Province, China, 2016-2022.BMC public health · 2024Article
- Emerging hantavirus infection in wild rodents captured in suburbs of Gwangju Metropolitan City, South Korea.PLoS neglected tropical diseases · 2022Article
- Acute pancreatitis associated with hemorrhagic fever with renal syndrome: a cohort study of 346 patients.BMC infectious diseases · 2021Article
- Analysis of misdiagnosed cases of hemorrhagic fever with renal syndrome in children: two cases and literature review.BMC nephrology · 2019Article
- Facing of Family Doctor with Hantavirus Infection.Open access Macedonian journal of medical sciences · 2019Article
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe potential effect of the inactivated hantavirus vaccine (IHV) remains controversial; however, it appears to be moderately effective for patients at high risk of hemorrhagic fever with renal syndrome (HFRS). This study of the epidemiology of HFRS from 2001 to 2017 aimed to examine those at high risk of HFRS in the Republic of Korea (ROK), particularly in terms of disease distribution according to age.
methodsRaw data of HFRS patients recorded in Korea from 2001 to 2017 were obtained from the Korean Center for Disease Control and Prevention. Patients were divided into three age groups: ≤39, 40-69, and ≥ 70 years. The incidence rate per 100,000 individuals in each age group was calculated using population data. The 12-month year was divided into three-month quarters, and the number and proportion of patients corresponding to each quarter were calculated. The effects of time, sex, and quarter on HFRS incidence were assessed in a Poisson regression analysis.
resultsFrom 2001 to 2017, 7048 HFRS patients were recorded nationwide. Among these patients, the proportion of patients aged ≥70 years increased gradually from 16.4% in 2001 to 43.9% in 2017. Regarding the quarter-year periods, the fourth quarter contained a significantly higher proportion of patients in the ≥70 years group (69.4%) compared to the other age groups. In the Poisson regression analysis, patients aged ≥70 years had a significantly higher relative risk of HFRS incidence within each quartile compared to those in the other age groups (2.102- and 10.029-fold in the third and fourth quarters, respectively). An analysis of disease incidence revealed a more distinct pattern in seasonal variation among those aged ≥70 years compared with other age groups.
conclusionsIn this study of the incidence of HFRS in the ROK, subjects aged ≥70 years exhibited a gradual increase in incidence and a distinct pattern of seasonal variation. These results may be important to identify individuals in Korea who are at high risk of developing HFRS. In future, active immunization programs will be needed to control HFRS among these high-risk groups in Korea.
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