Evidence map›Paper›PMID 30760120›Full record

ArticleThyroid : official journal of the American Thyroid Association2019

Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha.

Bernard Freudenthal, Samiksha Shetty, Natalie C Butterfield, John G Logan, Cho Rong Han, Xuguang Zhu, Inna Astapova, Anthony N Hollenberg, Sheue-Yann Cheng, J H Duncan Bassett and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thyroid : official journal of the American Thyroid Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Clinical Spectrum of Resistance to Thyroid Hormone Alpha in Children and AdultsJournal of clinical research in pediatric endocrinology · 2021
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Bernard Freudenthal1 Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, United Kingdom.
Samiksha Shetty1 Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, United Kingdom.
Natalie C Butterfield1 Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, United Kingdom.
John G Logan1 Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, United Kingdom.
Cho Rong Han2 Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Xuguang Zhu2 Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Inna Astapova3 Endocrinology, Metabolism and Nutrition, Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
Anthony N Hollenberg4 Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine and New York Presbyterian/Weill Cornell Medical Center, New York, New York.
Sheue-Yann Cheng2 Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
J H Duncan Bassett1 Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, United Kingdom.
Graham R Williams1 Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London, United Kingdom.
Imperial College London · GBNational Institutes of Health · USCornell University · USDuke University · US

Funding

Thyroid Hormone Receptors in Health and DiseaseZIABC008752 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CHENG, SHEUE-YANN · 2009 to 2025
$12.9M
COREPRESSOR REGULATION OF THYROID HORMONE ACTIONR01DK056123 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HOLLENBERG, ANTHONY N · 2000 to 2023
$7.6M
Corepressor Regulation of Nuclear Receptor ActionR56DK056123 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HOLLENBERG, ANTHONY N · 2009 to 2009
$425k
Medical Research Council MR/P018718/1NIDDK NIH HHS R01 DK056123NIDDK NIH HHS R56 DK056123Wellcome TrustWellcome Trust 110140/Z/15/ZWellcome Trust 110141/Z/15/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBone DensityBone DevelopmentCalcification, PhysiologicMiceMice, Inbred C57BLNuclear Receptor Co-Repressor 1Thyroid Hormone Receptors alphaThyroid Hormone Resistance SyndromeThyroxineVorinostatNcor1 protein, mouseNuclear Receptor Co-Repressor 1Thyroid Hormone Receptors alphaThyroxineVorinostatboneNCoR1RTH-αthyroid hormone receptor

Identifiers

PMID30760120
PMCPMC6533791
OpenAlexW2912500921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.