SynthesisCognitive behaviour therapy2020
Psychological and pharmacological treatments for generalized anxiety disorder (GAD): a meta-analysis of randomized controlled trials.
Synthesis in Cognitive behaviour therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Impacts of participatory arts-based interventions on well-being of older adults without dementia: an umbrella review and a conceptual artistic participation framework.The Gerontologist · 2026Pooled it
- Efficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials.European archives of psychiatry and clinical neuroscience · 2023Pooled it
- Efficacy of stand-alone digital mental health applications for anxiety and depression: A meta-analysis of randomized controlled trials.Journal of psychiatric research · 2023Pooled it
- The effectiveness of Internet-delivered treatment for generalized anxiety disorder: An updated systematic review and meta-analysis.Depression and anxiety · 2021Pooled it
- The effectiveness of metacognitive therapy on emotional distress tolerance and medication adherence in patients with generalized anxiety disorder: a pilot randomized controlled trial.BMC psychology · 2026Trial
- Digital Cognitive Behavioral Treatment for Generalized Anxiety Disorder: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Statistical methods to adjust for the effects on intervention compliance in randomized clinical trials where precision treatment rules are being developed.International journal of methods in psychiatric research · 2025Trial
- Efficacy of a Mobile App-Based Intervention for Young Adults With Anxiety Disorders: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Predictors of mental health outcomes of three refugee groups in an advocacy-based intervention: A precision medicine perspective.Journal of consulting and clinical psychology · 2024Trial
- A Precision Treatment Model for Internet-Delivered Cognitive Behavioral Therapy for Anxiety and Depression Among University Students: A Secondary Analysis of a Randomized Clinical Trial.JAMA psychiatry · 2023Trial
- Exploring the role of early maladaptive schemas and intolerance of uncertainty in generalized anxiety disorder.The British journal of clinical psychology · 2026Article
- The role of the duration of untreated illness (DUI) in generalized anxiety disorder: a cross-sectional, multicenter study.CNS spectrums · 2026Article
- Differences in brain functioning between obsessive-compulsive disorder and generalized anxiety disorder: a clinical study using functional near-infrared spectroscopy.Frontiers in psychiatry · 2026Article
- Changes in depression, anxiety, and post-traumatic stress symptoms among children and adolescents exposed to adverse childhood experiences following participation in the PROACT intervention in Nairobi, Kenya.Frontiers in psychiatry · 2026Article
- Approach-Avoidance Conflict Paradigms in Animal and Human Studies of Anxiety-A Narrative Review.Behavioral sciences (Basel, Switzerland) · 2025Review
- Validation of the Effectiveness of a Behavioral Activation-Based Digital App for Treatment of Depressive Symptoms: A Randomized Controlled Trial.Behavioral sciences (Basel, Switzerland) · 2025Article
- Network Analysis of Anxiety in Prostate Cancer Patients.Psycho-oncology · 2025Article
- Review
- Efficacy of electroacupuncture treatment for generalized anxiety disorder related insomnia: a study protocol for randomized controlled trial.Frontiers in psychiatry · 2025Article
- Group arts interventions for depression and anxiety among older adults: a systematic review and meta-analysis.Nature. Mental health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 4 countries.
Funding
Abstract
The purpose of this meta-analysis was to provide updated pooled effect sizes of evidence-based psychotherapies and medications for generalized anxiety disorder (GAD) and to investigate potential moderators of outcomes. Seventy-nine randomized controlled trials (RCT) including 11,002 participants with a diagnosis of GAD were included in a meta-analysis that tested the efficacy of psychotherapies or medications for GAD. Psychotherapy showed a medium to large effect size (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.