Evidence map›Paper›PMID 30760029›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2019

A mole rat's gut microbiota suggests selective influence of diet on microbial niche space and evolution.

Linda Ren, Robert A Holzknecht, Zoie E Holzknecht, Sanet H Kotzé, Dawn E Bowles, Shu S Lin, Erin A McKenney, William Parker

Abstract read
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Microbiome: Our opponents or allies in healthcare and medicine.Experimental biology and medicine (Maywood, N.J.) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Linda Ren1 Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Robert A Holzknecht1 Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Zoie E Holzknecht1 Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Sanet H Kotzé2 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town 8000, South Africa.
Dawn E Bowles1 Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Shu S Lin1 Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Erin A McKenney3 Department of Biology, Duke University, Durham, NC 27710, USA.
William Parker1 Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impact statementThe composition of the microbiota is of critical importance for health and disease, and is receiving increased scientific and medical scrutiny. Of particular interest is the role of changing diets as a function of agriculture and, perhaps to an even greater extent, modern food processing. To probe the connection between diet and the gut's microbial community, the microbiota from a mole rat, a rodent with a relatively unusual diet, was analyzed in detail, and the microbes found were compared with previously identified organisms. The results show evidence of an adaptive radiation of some microbial clades, but relative stability in others. This suggests that the microbiota, like the genome, carries with it housekeeping components as well as other components which can evolve rapidly when the environment changes. This study provides a very broad view of the niche space in the gut and how factors such as diet might influence that niche space.

Indexed as

Gastrointestinal MicrobiomeAnimalsBiological EvolutionDietEcosystemMole RatsDietevolutionfibermicrobiotamole ratniche

Identifiers

PMID30760029
PMCPMC6547004

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.