Evidence map›Paper›PMID 30759893›Full record

ReviewCancers2019

Lung Cancer Screening, Towards a Multidimensional Approach: Why and How?

Jonathan Benzaquen, Jacques Boutros, Charles Marquette, Hervé Delingette, Paul Hofman

Abstract readReview
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jonathan BenzaquenDepartment of Pulmonary Medicine and Oncology, Université Côte d'Azur, CHU de Nice, FHU OncoAge, Nice 06100, France. benzaquen.j@chu-nice.fr.
Jacques BoutrosDepartment of Pulmonary Medicine and Oncology, Université Côte d'Azur, CHU de Nice, FHU OncoAge, Nice 06100, France. boutros.j@chu-nice.fr.
Charles MarquetteDepartment of Pulmonary Medicine and Oncology, Université Côte d'Azur, CHU de Nice, FHU OncoAge, Nice 06100, France. marquette.c@chu-nice.fr.
Hervé DelingetteAsclepios Project Team, Sophia Antipolis-Mediterranee Research Centre, Université Côte d'Azur, FHU OncoAge, Inria, 06902 Sophia Antipolis, France. herve.delingette@inria.fr.
Paul HofmanInstitute of Research on Cancer and Ageing (IRCAN), Université Côte d'Azur, FHU OncoAge, CNRS, INSERM, 06107 Nice, France. hofman.p@chu-nice.fr.

Funding

Conseil Départemental des Alpes Maritimes 2014-8Ligue Départementale des Alpes Maritimes de Lutte contre le Cancer #2015-004Maskini foundation #2017-05
6 · The paper itself

Abstract

Early-stage treatment improves prognosis of lung cancer and two large randomized controlled trials have shown that early detection with low-dose computed tomography (LDCT) reduces mortality. Despite this, lung cancer screening (LCS) remains challenging. In the context of a global shortage of radiologists, the high rate of false-positive LDCT results in overloading of existing lung cancer clinics and multidisciplinary teams. Thus, to provide patients with earlier access to life-saving surgical interventions, there is an urgent need to improve LDCT-based LCS and especially to reduce the false-positive rate that plagues the current detection technology. In this context, LCS can be improved in three ways: (1) by refining selection criteria (risk factor assessment), (2) by using Computer Aided Diagnosis (CAD) to make it easier to interpret chest CTs, and (3) by using biological blood signatures for early cancer detection, to both spot the optimal target population and help classify lung nodules. These three main ways of improving LCS are discussed in this review.

Indexed as

artificial intelligencelung cancerscreening

Identifiers

PMID30759893
PMCPMC6406662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.