Evidence map›Paper›PMID 30759886›Full record

ArticlePharmaceutics2019

Improved Morphine-Loaded Hydrogels for Wound-Related Pain Relief.

Dinis Mateus, Joana Marto, Patrícia Trindade, Humberto Gonçalves, Ana Salgado, Paula Machado, António Melo-Gouveia, Helena M Ribeiro, António J Almeida

Abstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dinis MateusServiço Farmacêutico, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal. dinis_mateus@hotmail.com.
Joana MartoResearch Medicine Research Institute (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal. jmmarto@ff.ulisboa.pt.
Patrícia TrindadeServiço Farmacêutico, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal. ptrindade@ipolisboa.min-saude.pt.
Humberto GonçalvesServiço Farmacêutico, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal. hgoncalves@ipolisboa.min-saude.pt.
Ana SalgadoResearch Medicine Research Institute (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal. asalgado@ff.ulisboa.pt.
Paula MachadoLaboratório de Controlo Microbiológico, ADEIM, Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal. paula_v_machado@hotmail.com.
António Melo-GouveiaServiço Farmacêutico, Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisboa, Portugal. agouveia@ipolisboa.min-saude.pt.
Helena M RibeiroResearch Medicine Research Institute (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal. hribeiro@campus.ul.pt.
António J AlmeidaResearch Medicine Research Institute (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal. aalmeida@ff.ulisboa.pt.

Funding

Fundação para a Ciência e a Tecnologia UID/DTP/04138/2013Instituto Português de Oncologia de Lisboa not applicable
6 · The paper itself

Abstract

The use of morphine applied topically to painful wounds has potential advantages, such as dose reduction, fewer side effects and compound formulations, have been proposed for this purpose. Given the potential high impact of drug product quality on a patient's health, the aim of the present study was to develop two stable sterile hydrogels containing morphine hydrochloride, intended for topical application on painful wounds. Two carboxymethylcellulose sodium-based hydrogels were prepared containing 0.125%

Indexed as

hydrogelsmorphinepainful woundsquality risk managementskin ulcerstopical opioids

Identifiers

PMID30759886
PMCPMC6409998

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.