ArticleAnimals : an open access journal from MDPI2019
Effect of Morphine Administration on Social andNon-Social Play Behaviour in Calves.
Article in Animals : an open access journal from MDPI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Individual variation in play in young chickens - assessment and connection to affective state and personality.Scientific reports · 2026Article
- Milk allowance affects play responsiveness in calves.Animal welfare (South Mimms, England) · 2026Article
- From welfare indicator to welfare contributor: the role of play in building flexibility and resilience in captive animals.Proceedings. Biological sciences · 2025Review
- Cortisol stress response after musculoskeletal surgery: a narrative review.EFORT open reviews · 2025Review
- Opioid receptor signaling throughout ontogeny: Shaping neural and behavioral trajectories.Neuroscience and biobehavioral reviews · 2025Review
- Pain and pessimism affect calves' play behaviours post-disbudding.Discover animals · 2025Article
- Modulation of social and depression behaviors in cholestatic and drug-dependent mice: possible role of opioid receptors.Journal of diabetes and metabolic disorders · 2023Article
- Use of a Tri-Axial Accelerometer Can Reliably Detect Play Behaviour in Newborn Calves.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The objective of this study was to evaluate the effect of morphine on social and non-socialplay behaviour in calves. Twelve calves experienced four treatments in a cross over 2 × 2 factorialdesign: Calves received an intravenous injection of morphine or saline 10 min prior to being testedindividually or in pairs in an arena for 20 min. Play behaviour was continuously recorded in thearena test. Lying times were recorded in the home pen. Cortisol concentrations were measuredbefore and after testing. In the arena test, calves given morphine tended to perform more social playevents than calves given saline, however, morphine administration had no effect on locomotor play.Calves given morphine spent less time lying than calves given saline during the first 4 h afterreturning to the home pen. Cortisol concentrations were suppressed in calves given morphine.Administration of morphine appeared to increase social play but had no effect on locomotor playin calves. This study highlights the importance of investigating different aspects of play behaviourin animals as some may be more indicative of a positive affective state than others. More studiesinvestigating the effects of morphine on play are needed to confirm the results found in this study.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.