Evidence map›Paper›PMID 30759820›Full record

ArticleMolecules (Basel, Switzerland)2019

Small Molecule Docking of DNA Repair Proteins Associated with Cancer Survival Following PCNA Metagene Adjustment: A Potential Novel Class of Repair Inhibitors.

Leif E Peterson

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Leif E PetersonDepartment of Healthcare Policy and Research, Weill Cornell Medical College, Cornell University, New York City, NY 10065, USA. peterson.leif.e@gmail.com.
Cornell University · US

Funding

National Aeronautics and Space Administration NNX-12AO52A
6 · The paper itself

Abstract

Natural and synthetic small molecules from the NCI Developmental Therapeutics Program (DTP) were employed in molecular dynamics-based docking with DNA repair proteins whose RNA-Seq based expression was associated with overall cancer survival (OS) after adjustment for the

Indexed as

Blood-Brain BarrierDNA RepairDrug DesignERG1 Potassium ChannelHumansIntestinal AbsorptionLigandsMolecular Docking SimulationMolecular Dynamics SimulationNeoplasmsProliferating Cell Nuclear AntigenProtein BindingProteinsSmall Molecule LibrariesStructure-Activity RelationshipERG1 Potassium ChannelLigandsProliferating Cell Nuclear AntigenProteinsSmall Molecule LibrariesADMEDNA repairdockinginhibitionligandmolecular dynamicsPCNAreceptorsmall moleculetoxicology

Identifiers

PMID30759820
PMCPMC6384788
OpenAlexW2903547310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.