ArticleToxins2019
A Recurrent Motif: Diversity and Evolution of ShKT Domain Containing Proteins in the Vampire Snail
Article in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Multiple ShKT domain-containing MUL-1 proteins act as redox-responsive modulators of oxidative stress signaling in C. elegans.Molecules and cells · 2026Article
- Animal Venoms Targeting Cellular Mechanisms: Advances and Implications for Drug Discovery and Disease Therapy.Toxins · 2026Review
- Multi-omics characterization of toxin expression and producing organs in the predatory gastropods Monoplex corrugatus and Stramonita haemastoma.BMC genomics · 2026Article
- Molecular characterization of zinc metalloproteinase Nas-14 from Trichinella spiralis and its participation in intestinal invasion.PLoS neglected tropical diseases · 2025Article
- The proteotranscriptomic characterization of venom in the white seafanOpen biology · 2025Article
- Functional Characterization of ShK Domain-Containing Protein in the Plant-Parasitic NematodePlants (Basel, Switzerland) · 2024Article
- Collaborative Expression: Transcriptomics of Conus virgo Suggests Contribution of Multiple Secretory Glands to Venom Production.Journal of molecular evolution · 2023Article
- Whole Genome Duplication and Gene Evolution in the Hyperdiverse Venomous Gastropods.Molecular biology and evolution · 2023Article
- An informatic workflow for the enhanced annotation of excretory/secretory proteins ofComputational and structural biotechnology journal · 2023Article
- ShK-Domain-Containing Protein from a Parasitic Nematode ModulatesPathogens (Basel, Switzerland) · 2022Article
- Vexitoxins: conotoxin-like venom peptides from predatory gastropods of the genusProceedings. Biological sciences · 2022Article
- Structural and evolutionary insights into astacin metallopeptidases.Frontiers in molecular biosciences · 2022Article
- The Origin and Evolution of Antistasin-like Proteins in Leeches (Hirudinida, Clitellata).Genome biology and evolution · 2021Article
- The cnidarian parasitePeerJ · 2021Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteins of the ShK superfamily are characterized by a small conserved domain (ShKT), first discovered in small venom peptides produced by sea anemones, and acting as specific inhibitors of voltage-dependent and calcium-activated K⁺ channels. The ShK superfamily includes both small toxic peptides and larger multifunctional proteins with various functions. ShK toxins are often important components of animal venoms, where they perform different biological functions including neurotoxic and immunosuppressive effects. Given their high specificity and effectiveness, they are currently regarded as promising pharmacological lead compounds for the treatment of autoimmune diseases. Here, we report on the molecular analysis of ShKT domain containing proteins produced by the Mediterranean vampire snail
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