Evidence map›Paper›PMID 30759732›Full record

ArticleInternational journal of molecular sciences2019

Oxidative-Inflammatory Stress in Immune Cells from Adult Mice with Premature Aging.

Antonio Garrido, Julia Cruces, Noemí Ceprián, Elena Vara, Mónica de la Fuente

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Antonio GarridoDepartment of Genetics, Physiology and Microbiology (Animal Physiology Unit), School of Biology, Complutense University of Madrid (UCM), 28040 Madrid, Spain. antoniogarridobio@gmail.com.ORCID 0000-0003-3026-3330
Julia CrucesDepartment of Genetics, Physiology and Microbiology (Animal Physiology Unit), School of Biology, Complutense University of Madrid (UCM), 28040 Madrid, Spain. j.cruces@pdi.ucm.es.
Noemí CepriánDepartment of Genetics, Physiology and Microbiology (Animal Physiology Unit), School of Biology, Complutense University of Madrid (UCM), 28040 Madrid, Spain. nceprian@gmail.com.ORCID 0000-0001-7028-3083
Elena VaraDepartment of Biochemistry and Molecular Biology III, School of Medicine, Complutense University of Madrid (UCM), 28040 Madrid, Spain. evaraami@med.ucm.es.
Mónica de la FuenteDepartment of Genetics, Physiology and Microbiology (Animal Physiology Unit), School of Biology, Complutense University of Madrid (UCM), 28040 Madrid, Spain. mondelaf@bio.ucm.es.
Universidad Complutense de Madrid · ES

Funding

Instituto de Salud Carlos III PI15/01787Universidad Complutense de Madrid 910379
6 · The paper itself

Abstract

Oxidative and inflammatory stresses are closely related processes, which contribute to age-associated impairments that affect the regulatory systems such as the immune system and its immunosenescence. Therefore, the aim of this work was to confirm whether an oxidative/inflammatory stress occurs in immune cells from adult mice with premature aging, similar to that shown in leukocytes from chronologically old animals, and if this results in immunosenescence. Several oxidants/antioxidants and inflammatory/anti-inflammatory cytokines were analyzed in peritoneal leukocytes from adult female CD1 mice in two models of premature aging-(a) prematurely aging mice (PAM) and (b) mice with the deletion of a single allele (hemi-zygotic: HZ) of the tyrosine hydroxylase (

Indexed as

Aging, PrematureAnimalsAntioxidantsDisease Models, AnimalFemaleImmunosenescenceInflammationLeukocytesLymphocytesMiceMice, Inbred C57BLOxidative StressPhagocytesPhagocytosisAntioxidantsimmunosenescenceleukocytesoxi-inflamm-agingPAMpremature agingTH-HZ mice

Identifiers

PMID30759732
PMCPMC6387005
OpenAlexW2912385011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.