Evidence map›Paper›PMID 30759320›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2019

Striatal spreading depolarization: Possible implication in levodopa-induced dyskinetic-like behavior.

Antonio de Iure, Francesco Napolitano, Goichi Beck, Ana Quiroga Varela, Valentina Durante, Miriam Sciaccaluga, Petra Mazzocchetti, Alfredo Megaro, Michela Tantucci, Antonella Cardinale and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Brain-Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety-Like Behaviors in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 2 countries.

Antonio de IureNeurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy.
Francesco NapolitanoCeinge Biotecnologie Avanzate, Naples, Italy.
Goichi BeckYerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-8890-2743
Ana Quiroga VarelaNeurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy.
Valentina DuranteNeurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy.
Miriam SciaccalugaNeurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy.
Petra MazzocchettiNeurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy.
Alfredo MegaroNeurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy.
Michela TantucciNeurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy.
Antonella CardinaleDepartment of Experimental Medicine, Section of Physiology and Biochemistry, University of Perugia, Perugia, Italy.
Daniela PunzoDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, Caserta, Italy.
Andrea ManciniNeurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy.
Cinzia CostaNeurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy.
Veronica GhiglieriLaboratory of Neurophysiology, Santa Lucia Foundation, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Alessandro TozziDepartment of Experimental Medicine, Section of Physiology and Biochemistry, University of Perugia, Perugia, Italy.
Barbara PicconiLaboratory of Experimental Neurophysiology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Pisana, Rome, Italy.
Stella M PapaYerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Alessandro UsielloDepartment of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, Caserta, Italy.
Paolo CalabresiNeurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy.
University of Perugia · ITEmory University · USUniversity of Campania "Luigi Vanvitelli" · ITFederico II University Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

Regulation of Motor Function in Parkinson's DiseaseR01NS045962 · NINDS · EMORY UNIVERSITY · PI PAPA, STELLA M, TRAYNELIS, STEPHEN F · 2004 to 2022
$5.2M
Gene therapy targeting striatal dysfunction for Parkinson’s diseaseR01NS126924 · NINDS · EMORY UNIVERSITY · PI Stella M Papa · 2022 to 2026
$2.7M
Manipulating Gene Expression in the Dyskinesias of Parkinson's DiseaseR01NS073994 · NINDS · EMORY UNIVERSITY · PI MOURADIAN, M. MARAL, PAPA, STELLA M · 2011 to 2016
$2.4M
NINDS NIH HHS R01 NS045962NINDS NIH HHS R01 NS073994NINDS NIH HHS R01 NS126924
6 · The paper itself

Abstract

objectiveSpreading depolarization (SD) is a transient self-propagating wave of neuronal and glial depolarization coupled with large membrane ionic changes and a subsequent depression of neuronal activity. Spreading depolarization in the cortex is implicated in migraine, stroke, and epilepsy. Conversely, spreading depolarization in the striatum, a brain structure deeply involved in motor control and in Parkinson's disease (PD) pathophysiology, has been poorly investigated.

methodsWe characterized the participation of glutamatergic and dopaminergic transmission in the induction of striatal spreading depolarization by using a novel approach combining optical imaging, measurements of endogenous DA levels, and pharmacological and molecular analyses.

resultsWe found that striatal spreading depolarization requires the concomitant activation of D1-like DA and N-methyl-d-aspartate receptors, and it is reduced in experimental PD. Chronic l-dopa treatment, inducing dyskinesia in the parkinsonian condition, increases the occurrence and speed of propagation of striatal spreading depolarization, which has a direct impact on one of the signaling pathways downstream from the activation of D1 receptors.

conclusionStriatal spreading depolarization might contribute to abnormal basal ganglia activity in the dyskinetic condition and represents a possible therapeutic target. © 2019 International Parkinson and Movement Disorder Society.

Indexed as

AnimalsAntineoplastic Combined Chemotherapy ProtocolsAntiparkinson AgentsCorpus StriatumDopaminergic NeuronsDyskinesia, Drug-InducedLevodopaNeuronsNitrogen Mustard CompoundsParkinsonian DisordersPrednisoloneProcarbazineRatsRats, WistarSynaptic TransmissionVincristineAntiparkinson AgentsLevodopaNitrogen Mustard CompoundsPrednisoloneProcarbazineVincristineD1 like receptorLIDsParkinson's diseaseSpreading depolarizationStriatum

Identifiers

PMID30759320
PMCPMC8006568
OpenAlexW2911846285

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.