Concave-shaped transparent electrode to simultaneously monitor electrical activity from multiple sites within the optical sampling area of the intact rat cerebral cortex.

Noriyuki Hama, Minako Kawai, Shin-Ichi Ito, Yuki Yoshida, Yasuhisa Fujita, Akihiko Hirota

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Article in The journal of physiological sciences : JPS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Noriyuki HamaDepartment of Neural and Muscular Physiology, Shimane University School of Medicine, Izumo, Shimane, 693-8501, Japan. hnori@med.shimane-u.ac.jp.

Minako KawaiDepartment of Neural and Muscular Physiology, Shimane University School of Medicine, Izumo, Shimane, 693-8501, Japan.

Shin-Ichi ItoDepartment of Neural and Muscular Physiology, Shimane University School of Medicine, Izumo, Shimane, 693-8501, Japan.

Yuki YoshidaInterdisciplinary Graduate School of Science and Engineering, Shimane University, Matsue, Shimane, 690-8504, Japan.

Yasuhisa FujitaInterdisciplinary Graduate School of Science and Engineering, Shimane University, Matsue, Shimane, 690-8504, Japan.

Akihiko HirotaDepartment of Neural and Muscular Physiology, Shimane University School of Medicine, Izumo, Shimane, 693-8501, Japan.

Funding

Japan Society for the Promotion of Science KAKENHI (21650095)

6 · The paper itself

Abstract

We have developed a concave-shaped transparent electrode unit that enables the placement of several electrodes within the optical sampling area on the spherical surface of the rat brain. This concave-shaped transparent electrode unit consists of an insulator base (a plano-concave lens) and a gallium-doped zinc oxide film that is a transparent conductor coating the base. Most of the unit is wrapped in an insulator film made of silicon dioxide, and the few areas left unwrapped act as electrodes. In the study reported here this newly developed transparent electrode unit worked well within the optical detection area without affecting optical recording. We applied this unit to our multiple-site optical recording system for membrane potential in order to eliminate pulsation artifacts and succeeded in optically recording spontaneous neural activity, including small changes in membrane potential, in the cerebral cortex in a single-sweep recording.

Indexed as

AnimalsCerebral CortexElectric StimulationElectrodesFemaleMembrane PotentialsNervous System Physiological PhenomenaRatsRats, Sprague-DawleyCerebral cortexEpifluorescence opticsSingle-sweep optical recordingSpontaneous neural activityTransparent electrodeVoltage-sensitive dye

Identifiers

PMID30758781

DOI10.1007/s12576-019-00663-y

PMCPMC10717891

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.