Evidence map›Paper›PMID 30758769›Full record

ArticleVirus genes2019

The BeWo cell line derived from a human placental choriocarcinoma is permissive for respiratory syncytial virus infection.

M A Velázquez-Cervantes, M Martínez-Castillo, L D González-García, T A Vargas-Pavía, M G Martínez-Salazar, I Mancilla-Herrera, G León-Reyes, J García-Cordero, A C Helguera-Repetto, M León-Juárez

Abstract read
PubMed Publisher
In one paragraph

Article in Virus genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

M A Velázquez-CervantesDepartamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Col. Lomas Virreyes, CP 11000, Mexico City, Mexico.
M Martínez-CastilloDepartamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Col. Lomas Virreyes, CP 11000, Mexico City, Mexico.
L D González-GarcíaDepartamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Col. Lomas Virreyes, CP 11000, Mexico City, Mexico.
T A Vargas-PavíaDepartamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Col. Lomas Virreyes, CP 11000, Mexico City, Mexico.
M G Martínez-SalazarDepartamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Col. Lomas Virreyes, CP 11000, Mexico City, Mexico.
I Mancilla-HerreraDepartamento de Infectología e Inmunología, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Col. Lomas Virreyes, CP 11000, Mexico City, Mexico.
G León-ReyesDepartamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Col. Lomas Virreyes, CP 11000, Mexico City, Mexico.
J García-CorderoDepartamento de Biomedicina Molecular, Centro de Investigación y Estudios Avanzados del I.P.N, Av. Instituto Politécnico 2508 Co. San Pedro Zacatenco, CP 07360, Mexico City, Mexico.
A C Helguera-RepettoDepartamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Col. Lomas Virreyes, CP 11000, Mexico City, Mexico.
M León-JuárezDepartamento de Inmunobioquímica, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Col. Lomas Virreyes, CP 11000, Mexico City, Mexico. moisesleoninper@gmail.com.
Instituto Nacional de Perinatología · MXInstituto Politécnico Nacional · MX

Funding

Consejo Nacional de Ciencia y Tecnología CB-2015-01-255007Instituto Nacional de Perinatología 212250-3210-21007-03-15
6 · The paper itself

Abstract

The respiratory syncytial virus (RSV) is the main pathogen associated with upper respiratory tract infections during early childhood. Vertical transmission of this virus has been suggested in humans, based on observations recorded during animal studies that revealed an association of RSV with persistent structural and functional changes in the developing lungs of the offspring. However, human placentas have not yet been evaluated for susceptibility to RSV infection. In this study, we examined the capacity of RSV to infect a human trophoblast model, the BeWo cell line. Our results suggest that BeWo cells are susceptible to RSV infection since they allow RNA viral replication, viral protein translation, leading to the production of infectious RSV particles. In this report, we demonstrate that a human placenta model system, consisting of BeWo cells, is permissive to RSV infection. Thus, the BeWo cell line may represent a useful model for studies that aim to characterize the events of a possible RSV infection at the human maternal-fetal interface.

Indexed as

Cell Line, TumorChoriocarcinomaFemaleHumansPlacentaPregnancyRespiratory Syncytial VirusesRespiratory Syncytial Virus InfectionsRNA, ViralRNA, ViralBeWo cellsPlacentaRespiratory syncytial virusTrophoblastViral cycle replication

Identifiers

PMID30758769
OpenAlexW2911881024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.