Evidence map›Paper›PMID 30758695›Full record

SynthesisInflammopharmacology2019

The effects of coenzyme Q10 supplementation on biomarkers of inflammation and oxidative stress in among coronary artery disease: a systematic review and meta-analysis of randomized controlled trials.

Mohammad Vahid Jorat, Reza Tabrizi, Fariba Kolahdooz, Maryam Akbari, Maryamalsadat Salami, Seyed Taghi Heydari, Zatollah Asemi

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Inflammopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 9 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 9 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Coenzyme QInternational journal of molecular sciences · 2020
    Pooled it
  10. Trial
  11. Review
  12. Review
  13. The Consumption of Beeswax Alcohol (BWA, RaydelAntioxidants (Basel, Switzerland) · 2024
    Article
  14. Review
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mohammad Vahid JoratDepartment of Cardiology, Shiraz University of Medical Sciences, Shiraz, Iran.
Reza TabriziHealth Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Fariba KolahdoozIndigenous and Global Health Research Group, Department of Medicine, University of Alberta, Edmonton, Canada.
Maryam AkbariHealth Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Maryamalsadat SalamiShiraz University of Medical Sciences, Shiraz, Iran.
Seyed Taghi HeydariHealth Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Zatollah AsemiResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. asemi_r@yahoo.com.
Shiraz University of Medical Sciences · IRKashan University of Medical Sciences · IRUniversity of Alberta · CA

Funding

Shiraz University of Medical Sciences 97155
6 · The paper itself

Abstract

objectiveSystemic inflammation and oxidative stress significantly contribute in developing coronary artery disease (CAD). This systematic review and meta-analysis was aimed to determine the effects of coenzyme Q10 (CoQ10) supplementation on biomarkers of inflammation and oxidative stress among patients with CAD.

methodsThe electronic databases including MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Library databases were systematically searched until Oct 2018. The quality assessment and heterogeneity of the selected randomized clinical Trials (RCTs) were examined using the Cochrane Collaboration risk of bias tool, and Q and I

resultsA total of 13 clinical RCTs of 912 potential citations were found to be eligible for the current meta-analysis. The pooled findings for biomarkers of inflammation and oxidative stress demonstrated that CoQ10 supplementation significantly increased superoxide dismutase (SOD) (SMD 2.63; 95% CI, 1.17, 4.09, P < 0.001; I

conclusionsOverall, this meta-analysis demonstrated CoQ10 supplementation increased SOD and CAT, and decreased MDA and diene levels, but did not affect CRP, TNF-α, IL-6, and GPx levels among patients with CAD.

Indexed as

AnimalsBiomarkersCoronary Artery DiseaseDietary SupplementsHumansInflammationOxidative StressRandomized Controlled Trials as TopicUbiquinoneBiomarkerscoenzyme Q10UbiquinoneCoQ10Coronary artery diseaseInflammationMeta-analysisOxidative stress

Identifiers

PMID30758695
OpenAlexW2911670512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.