ReviewCellular and molecular life sciences : CMLS2019
Establishment and maintenance of blood-lymph separation.
Review in Cellular and molecular life sciences : CMLS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.Translational neurodegeneration · 2026Review
- Lymphedema: current treatment strategies and future directions in tissue engineering.Frontiers in medicine · 2026Review
- Thoracic duct outflow obstruction increases thoracic duct pressure above central venous pressure supporting thoracic duct decompression.JVS-vascular science · 2026Article
- Lymphatic System Development and Function.Current cardiology reports · 2024Review
- Lymphatic failure and lymphatic interventions: Knowledge gaps and future directions for a new frontier in congenital heart disease.Seminars in pediatric surgery · 2024Review
- Unveiling the Spatiotemporal Diversity of the Endothelium in Development: A Multi-Omics Approach.Circulation research · 2024Article
- Temporospatial inhibition of Erk signaling is required for lymphatic valve formation.Signal transduction and targeted therapy · 2023Article
- Integrated Pathogenesis of Vascular and Cardiac Valve Disease.Circulation research · 2023Article
- Cation Channelopathies: Novel Insights into Generalized Lymphatic Dysplasia.Circulation research · 2022Article
- The Lymphatic System: An Osteopathic Review.Cureus · 2021Review
- Vascular and Lymphatic Malformations: Perspectives From Human and Vertebrate Studies.Circulation research · 2021Article
- The evolving cardiac lymphatic vasculature in development, repair and regeneration.Nature reviews. Cardiology · 2021Review
- Lymphatic blood filling in CLEC-2-deficient mouse models.Platelets · 2021Article
- Lymphatic Programing and Specialization in Hybrid Vessels.Frontiers in physiology · 2020Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hippocratic Corpus, a collection of Greek medical literature, described the functional anatomy of the lymphatic system in the fifth century B.C. Subsequent studies in cadavers and surgical patients firmly established that lymphatic vessels drain extravasated interstitial fluid, also known as lymph, into the venous system at the bilateral lymphovenous junctions. Recent advances revealed that lymphovenous valves and platelet-mediated hemostasis at the lymphovenous junctions maintain life-long separation of the blood and lymphatic vascular systems. Here, we review murine models that exhibit failure of blood-lymph separation to highlight the novel mechanisms and molecular targets for the modulation of lymphatic disorders. Specifically, we focus on the transcription factors, cofactors, and signaling pathways that regulate lymphovenous valve development and platelet-mediated lymphovenous hemostasis, which cooperate to maintain blood-lymph separation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.