ReviewApplied microbiology and biotechnology2019
Citric acid and itaconic acid accumulation: variations of the same story?
Review in Applied microbiology and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Production, Optimization and Characterization of Biobased Itaconic Acid fromInternational journal of molecular sciences · 2026Article
- Draft genome assembly of hyper citric acid-producing Aspergillus niger mutant strain developed through gamma radiation bombardment.BMC genomic data · 2026Article
- Extracellular Phosphate Availability ImpactsJournal of fungi (Basel, Switzerland) · 2025Article
- Pseudomonadal itaconate degradation gene cluster encodes enzymes for methylsuccinate utilization.Communications biology · 2025Article
- ReprogrammingScience advances · 2024Article
- Improving dietary citric acid production by the wild-typeFood science & nutrition · 2024Article
- Liposomes Affect Protein Release and Stability of ITA-Modified PLGA-PEG-PLGA Hydrogel Carriers for Controlled Drug Delivery.Biomacromolecules · 2024Article
- Engineering a Phosphoketolase Pathway to Supplement Cytosolic Acetyl-CoA inJournal of fungi (Basel, Switzerland) · 2023Article
- Citric Acid and Magnolol AmeliorateAnimals : an open access journal from MDPI · 2023Article
- Manganese(II) ions suppress the transcription of the citrate exporter encoding geneFrontiers in bioengineering and biotechnology · 2023Article
- Recent Advances in Biotechnological Itaconic Acid Production, and Application for a Sustainable Approach.Polymers · 2021Review
- Butyric and Citric Acids and Their Salts in Poultry Nutrition: Effects on Gut Health and Intestinal Microbiota.International journal of molecular sciences · 2021Review
- Turning Inside Out: Filamentous Fungal Secretion and Its Applications in Biotechnology, Agriculture, and the Clinic.Journal of fungi (Basel, Switzerland) · 2021Review
- The Role of Metal Ions in Fungal Organic Acid Accumulation.Microorganisms · 2021Review
- Enzymatic degradation of xyloglucans by Aspergillus species: a comparative view of this genus.Applied microbiology and biotechnology · 2021Review
- Ustilaginaceae Biocatalyst for Co-Metabolism of COJournal of fungi (Basel, Switzerland) · 2021Article
- Twists and Turns in the Salicylate Catabolism ofmSystems · 2021Article
- Overflow Metabolism inFrontiers in fungal biology · 2021Article
- Glycosphingolipids in Filamentous Fungi: Biological Roles and Potential Applications in Cosmetics and Health Foods.Frontiers in microbiology · 2021Review
- Carbon-Source Dependent Interplay of Copper and Manganese Ions Modulates the Morphology and Itaconic Acid Production inFrontiers in microbiology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Citric acid production by Aspergillus niger and itaconic acid production by Aspergillus terreus are two major examples of technical scale fungal fermentations based on metabolic overflow of primary metabolism. Both organic acids are formed by the same metabolic pathway, but whereas citric acid is the end product in A. niger, A. terreus performs two additional enzymatic steps leading to itaconic acid. Despite of this high similarity, the optimization of the production process and the mechanism and regulation of overflow of these two acids has mostly been investigated independently, thereby ignoring respective knowledge from the other. In this review, we will highlight where the similarities and the real differences of these two processes occur, which involves various aspects of medium composition, metabolic regulation and compartmentation, transcriptional regulation, and gene evolution. These comparative data may facilitate further investigations of citric acid and itaconic acid accumulation and may contribute to improvements in their industrial production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.