Evidence map›Paper›PMID 30758328›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019

Impact of adult attention deficit hyperactivity disorder and medication status on sleep/wake behavior and molecular circadian rhythms.

A N Coogan, M Schenk, D Palm, A Uzoni, J Grube, A H Tsang, I Kolbe, N M McGowan, R Wandschneider, M Colla and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. The Efficacy ofFrontiers in neurology · 2022
    Pooled it
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  8. Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
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  20. Methods to Develop anFrontiers in psychiatry · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

A N CooganDepartment of Psychology, Maynooth University, National University of Ireland, Maynooth, Ireland.
M SchenkDepartment of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany.
D PalmDepartment of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany.
A UzoniDepartment of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany.ORCID http://orcid.org/0000-0001-8323-0394
J GrubeInstitute for Neurobiology, University of Lübeck, Lübeck, Germany.
A H TsangInstitute for Neurobiology, University of Lübeck, Lübeck, Germany.
I KolbeInstitute for Neurobiology, University of Lübeck, Lübeck, Germany.
N M McGowanDepartment of Psychology, Maynooth University, National University of Ireland, Maynooth, Ireland.
R WandschneiderDepartment of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany.
M CollaDepartment of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany.
H OsterInstitute for Neurobiology, University of Lübeck, Lübeck, Germany.
J ThomeDepartment of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany. johannes.thome@med.uni-rostock.de.de.
F FaltracoDepartment of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany.
University of Rostock · DEUniversity of Lübeck · DENational University of Ireland, Maynooth · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition that has been strongly associated with changes in sleep and circadian rhythms. Circadian rhythms are near 24-h cycles that are primarily generated by an endogenous circadian timekeeping system, encoded at the molecular level by a panel of clock genes. Stimulant and non-stimulant medication used in the management of ADHD has been shown to potentially impact on circadian processes and their behavioral outputs. In the current study, we have analyzed circadian rhythms in daily activity and sleep, and the circadian gene expression in a cohort of healthy controls (N = 22), ADHD participants not using ADHD-medication (N = 17), and participants with ADHD and current use of ADHD medication (N = 17). Rhythms of sleep/wake behavior were assessed via wrist-worn actigraphy, whilst rhythms of circadian gene expression were assessed ex-vivo in primary human-derived dermal fibroblast cultures. Behavioral data indicate that patients with ADHD using ADHD-medication have lower relative amplitudes of diurnal activity rhythms, lower sleep efficiency, more nocturnal activity but not more nocturnal wakenings than both controls and ADHD participants without medication. At the molecular level, there were alterations in the expression of PER2 and CRY1 between ADHD individuals with no medication compared to medicated ADHD patients or controls, whilst CLOCK expression was altered in patients with ADHD and current medication. Analysis of fibroblasts transfected with a BMAL1:luc reporter showed changes in the timing of the peak expression across the three groups. Taken together, these data support the contention that both ADHD and medication status impact on circadian processes.

Indexed as

Circadian RhythmActigraphyAdultAttention Deficit Disorder with HyperactivityCells, CulturedCircadian ClocksCircadian Rhythm Signaling Peptides and ProteinsCLOCK ProteinsCryptochromesFemaleFibroblastsGene ExpressionHumansMaleMiddle AgedPeriod Circadian ProteinsCircadian Rhythm Signaling Peptides and ProteinsCLOCK protein, humanCLOCK ProteinsCRY1 protein, humanCryptochromesPER2 protein, humanPeriod Circadian Proteins

Identifiers

PMID30758328
PMCPMC6785110
OpenAlexW2912018040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.