ArticlePediatric research2019
Ventricular remodeling in preterm infants: computational cardiac magnetic resonance atlasing shows significant early remodeling of the left ventricle.
Article in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 55 citations in OpenAlex.
- Postnatal evolution of electrocardiographic parameters in preterm infants: a prospective longitudinal cohort study.European journal of pediatrics · 2026Article
- ECG Changes in Tetralogy of Fallot: Association with Right Ventricular Function, Early Age of Repair and Prematurity.Pediatric cardiology · 2026Article
- Utilization of integrated lung ultrasound and targeted neonatal echocardiography in preterm infant follow-up: is it feasible? Assessing value and practical challenges.European journal of pediatrics · 2026Review
- Electrocardiogram characteristics and possible associated factors in healthy Japanese children: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.BMC pediatrics · 2025Article
- Reference ranges of left ventricular diastolic multimodal ultrasound parameters in stable preterm infants in the early and late neonatal intensive care admission period.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Respiratory distress syndrome is the poster child for neonatology.Pediatric research · 2025Article
- Perinatal Inflammation Results in Sex-Dependent Cardiac Dysfunction.Journal of cardiovascular development and disease · 2024Article
- Cardiac Mechanics Evaluation in Preschool-Aged Children with Preterm Birth History: A Speckle Tracking and 4D Echocardiography Study.Journal of clinical medicine · 2024Article
- Understanding the preterm human heart: What do we know so far?Anatomical record (Hoboken, N.J. : 2007) · 2022Review
- Reshaping the Preterm Heart: Shifting Cardiac Renin-Angiotensin System Towards Cardioprotection in Rats Exposed to Neonatal High-Oxygen Stress.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Right Ventricular Structure and Function in Young Adults Born Preterm at Very Low Birth Weight.Journal of clinical medicine · 2021Article
- Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment.Journal of clinical medicine · 2021Review
- Article
- Cardiac magnetic resonance imaging: insights into developmental programming and its consequences for aging.Journal of developmental origins of health and disease · 2021Review
- The Preterm Heart-Brain Axis in Young Adulthood: The Impact of Birth History and Modifiable Risk Factors.Journal of clinical medicine · 2021Article
- The Transitional Heart: From Early Embryonic and Fetal Development to Neonatal Life.Fetal diagnosis and therapy · 2020Review
- Dilated hypertrophy: a distinct pattern of cardiac remodeling in preterm infants.Pediatric research · 2020Observational
- Biochemical and toxicological effect of diazepam in stress-induced cardiac dysfunctions.Toxicology reports · 2020Article
- The preterm heart: a unique cardiomyopathy?Pediatric research · 2019Article
- Preterm Birth Is a Novel, Independent Risk Factor for Altered Cardiac Remodeling and Early Heart Failure: Is it Time for a New Cardiomyopathy?Current treatment options in cardiovascular medicine · 2019Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPremature birth is associated with ventricular remodeling, early heart failure, and altered left ventricular (LV) response to physiological stress. Using computational cardiac magnetic resonance (CMR) imaging, we aimed to quantify preterm ventricular remodeling in the neonatal period, and explore contributory clinical factors.
methodsSeventy-three CMR scans (34 preterm infants, 10 term controls) were performed to assess in-utero development and preterm ex-utero growth. End-diastolic computational atlases were created for both cardiac ventricles; t statistics, linear regression modeling, and principal component analysis (PCA) were used to describe the impact of prematurity and perinatal factors on ventricular volumetrics, ventricular geometry, myocardial mass, and wall thickness.
resultsAll preterm neonates demonstrated greater weight-indexed LV mass and higher weight-indexed end-diastolic volume at term-corrected age (P < 0.05 for all preterm gestations). Independent associations of increased term-corrected age LV myocardial wall thickness were (false discovery rate <0.05): degree of prematurity, antenatal glucocorticoid administration, and requirement for >48 h postnatal respiratory support. PCA of LV geometry showed statistical differences between all preterm infants at term-corrected age and term controls.
conclusionsComputational CMR demonstrates that significant LV remodeling occurs soon after preterm delivery and is associated with definable clinical situations. This suggests that neonatal interventions could reduce long-term cardiac dysfunction.
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