Evidence map›Paper›PMID 30758322›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019

TrkB-dependent disinhibition of the nucleus accumbens is enhanced by ethanol.

Mary H Patton, Katherine E Padgett, Paige N McKeon, Houman Qadir, Michael S Patton, Chaoqi Mu, Bradley M Roberts, Brian N Mathur

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Cocaine restricts nucleus accumbens feedforward drive through a monoamine-independent mechanism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  3. Heterosynaptic GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mary H PattonDepartment of Pharmacology, University of Maryland School of Medicine, 670 W. Baltimore St. HSF III 9179, Baltimore, MD, 21201, USA.
Katherine E PadgettDepartment of Pharmacology, University of Maryland School of Medicine, 670 W. Baltimore St. HSF III 9179, Baltimore, MD, 21201, USA.
Paige N McKeonDepartment of Pharmacology, University of Maryland School of Medicine, 670 W. Baltimore St. HSF III 9179, Baltimore, MD, 21201, USA.
Houman QadirDepartment of Pharmacology, University of Maryland School of Medicine, 670 W. Baltimore St. HSF III 9179, Baltimore, MD, 21201, USA.
Michael S PattonDepartment of Pharmacology, University of Maryland School of Medicine, 670 W. Baltimore St. HSF III 9179, Baltimore, MD, 21201, USA.
Chaoqi MuDepartment of Pharmacology, University of Maryland School of Medicine, 670 W. Baltimore St. HSF III 9179, Baltimore, MD, 21201, USA.
Bradley M RobertsDepartment of Pharmacology, University of Maryland School of Medicine, 670 W. Baltimore St. HSF III 9179, Baltimore, MD, 21201, USA.
Brian N MathurDepartment of Pharmacology, University of Maryland School of Medicine, 670 W. Baltimore St. HSF III 9179, Baltimore, MD, 21201, USA. bmathur@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Striatal Microcircuit Dynamics of Ethanol HabitsR01AA024845 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI BRIAN NEIL MATHUR · 2016 to 2026
$3.9M
Ethanol Remodeling of Striatal MicrocircuitsK22AA021414 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI MATHUR, BRIAN NEIL · 2013 to 2015
$658k
Characterization of a Mouse Model of Werner SyndromeR03AG024683 · NIA · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI CHANG, SANDY S · 2004 to 2005
$151k
Mechanism of protection against ethanol sculpting of a striatal microcircuitF31AA024683 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI PATTON, MARY H. · 2016 to 2017
$61k
NIAAA NIH HHS F31 AA024683NIAAA NIH HHS K22 AA021414NIAAA NIH HHS R01 AA024845U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) F31AA024683U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) K22AA021414U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) R01AA024845Whitehall Foundation (Whitehall Foundation, Inc.) 2014-12-68
6 · The paper itself

Abstract

The nucleus accumbens is a critical integration center for reward-related circuitry and is comprised primarily of medium spiny projection neurons. The dynamic balance of excitation and inhibition onto medium spiny neurons determines the output of this structure. While nucleus accumbens excitatory synaptic plasticity is well-characterized, inhibitory synaptic plasticity mechanisms and their potential relevance to shaping motivated behaviors is poorly understood. Here we report the discovery of long-term depression of inhibitory synaptic transmission in the mouse nucleus accumbens core. This long-term depression is postsynaptically expressed, tropomyosin kinase B (TrkB) receptor-mediated, and augmented in the presence of ethanol. Our findings support the emerging view that TrkB signaling regulates inhibitory synaptic plasticity and suggest this mechanism in the nucleus accumbens as a target for ethanol modulation of reward.

Indexed as

Long-Term Synaptic DepressionNeural InhibitionNucleus AccumbensSignal TransductionAnimalsCentral Nervous System DepressantsEthanolFemaleMaleMembrane GlycoproteinsMiceMice, Inbred C57BLProtein-Tyrosine KinasesReceptor, trkBCentral Nervous System DepressantsEthanolMembrane GlycoproteinsNtrk2 protein, mouseProtein-Tyrosine KinasesReceptor, trkB

Identifiers

PMID30758322
PMCPMC6461768
OpenAlexW2912896859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.