Evidence map›Paper›PMID 30758285›Full record

ArticleeLife2019

Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis.

Vikash Verma, Thomas J Maresca

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

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  8. Septins mediate a microtubule-actin crosstalk that enables actin growth on microtubules.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vikash VermaBiology Department, University of Massachusetts, Amherst, United States.ORCID 0000-0003-2371-4164
Thomas J MarescaBiology Department, University of Massachusetts, Amherst, United States.ORCID 0000-0003-2214-8674
University of Massachusetts Amherst · US

Funding

Mechano-molecular regulation of kinetochore functionR01GM107026 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MARESCA, THOMAS JOSEPH · 2013 to 2022
$2.7M
NIGMS NIH HHS GM107026NIGMS NIH HHS R01 GM107026
6 · The paper itself

Abstract

Microtubules (MTs) are essential for cleavage furrow positioning during cytokinesis, but the mechanisms by which MT-derived signals spatially define regions of cortical contractility are unresolved. In this study cytokinesis regulators visualized in

Indexed as

CytokinesisSignal TransductionAmino Acid MotifsAnaphaseAnimalsConcanavalin ADrosophila melanogasterDrosophila ProteinsGreen Fluorescent ProteinsMicrotubulesMyosinsProtein Bindingrho GTP-Binding ProteinsConcanavalin ADrosophila Proteinsenhanced green fluorescent proteinGreen Fluorescent ProteinsMyosinsRho1 protein, Drosophilarho GTP-Binding ProteinsAurora B Kinasecell biologyCentralspindlinCytokinesisD. melanogasterEct2microtubulesMKLP1Polo kinaseRacGAP50CRhoA

Identifiers

PMID30758285
PMCPMC6398982
OpenAlexW2911923201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.