Evidence map›Paper›PMID 30756523›Full record

ArticleDrug testing and analysis2019

Correlation of creatinine- and specific gravity-normalized free and glucuronidated urine cannabinoid concentrations following smoked, vaporized, and oral cannabis in frequent and occasional cannabis users.

Marilyn A Huestis, Benjamin C Blount, Daniel F Milan, Matthew N Newmeyer, Jennifer Schroeder, Michael L Smith

Open access · greenAbstract read
In one paragraph

Article in Drug testing and analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. N-acetylcysteine for youth cannabis use disorder: randomized controlled trial main findings.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Trial
  2. Trial
  3. Article
  4. Article
  5. ΔCardiovascular toxicology · 2023
    Article
  6. Observational
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Marilyn A HuestisChemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21124, USA.
Benjamin C BlountDivision of Laboratory Sciences, Tobacco and Volatiles Branch, Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA, 30341, USA.
Daniel F MilanDivision of Laboratory Sciences, Tobacco and Volatiles Branch, Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA, 30341, USA.
Matthew N NewmeyerChemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21124, USA.
Jennifer SchroederOffice of the Clinical Director, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, 21124, USA.
Michael L SmithHuestis and Smith Toxicology, LLC, Severna Park, MD, 21146, USA.
Centers for Disease Control and Prevention · USNational Institute on Drug Abuse · USOffice of Chief Medical Examiner · USSmiths Detection (United States) · USThomas Jefferson University · US

Funding

CDC HHSIntramural CDC HHS CC999999NIDA NIH HHS
6 · The paper itself

Abstract

Variability in urine dilution complicates urine cannabinoid test interpretation. Normalizing urine cannabinoid concentrations to specific gravity (SG) or creatinine was proposed to account for donors' hydration states. In this study, all urine voids were individually collected from eight frequent and eight occasional cannabis users for up to 85 hours after each received on separate occasions 50.6 mg Δ9-tetrahydrocannabinol (THC) by smoking, vaporization, and oral ingestion in a randomized, within-subject, double-blind, double-dummy, placebo-controlled protocol. Each urine void was analyzed for 11 cannabinoids and phase I and II metabolites by liquid chromatography-tandem mass spectrometry (LC-MS/MS), SG, and creatinine. Normalized urine concentrations were log

Indexed as

Administration, OralAdultCannabinoidsCreatinineDouble-Blind MethodHumansMarijuana SmokingMiddle AgedPlacebo EffectSpecific GravityVolatilizationYoung AdultCannabinoidsCreatininecreatininespecific gravityurine cannabinoids

Identifiers

PMID30756523
PMCPMC11301777
OpenAlexW2912238467

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.